To install click the Add extension button. That's it.

The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. You could also do it yourself at any point in time.

How to transfigure the Wikipedia

Would you like Wikipedia to always look as professional and up-to-date? We have created a browser extension. It will enhance any encyclopedic page you visit with the magic of the WIKI 2 technology.

Try it — you can delete it anytime.

Install in 5 seconds
4,5
Kelly Slayton
Congratulations on this excellent venture… what a great idea!
Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
Live Statistics
English Articles
Improved in 24 Hours
Added in 24 Hours
Languages
Recent
Show all languages
What we do. Every page goes through several hundred of perfecting techniques; in live mode. Quite the same Wikipedia. Just better.
Great Wikipedia has got greater.
.
Leo
Newton
Brights
Milds

SH-I-048A

From Wikipedia, the free encyclopedia

SH-I-048A
Legal status
Legal status
Identifiers
  • (3S)-7-bromo-5-(2-fluorophenyl)-3-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC16H12BrFN2O
Molar mass347.187 g·mol−1
3D model (JSmol)
  • Fc3ccccc3C2=N[C@@H](C)C(=O)Nc1ccc(Br)cc12
  • InChI=1S/C16H12BrFN2O/c1-9-16(21)20-14-7-6-10(17)8-12(14)15(19-9)11-4-2-3-5-13(11)18/h2-9H,1H3,(H,20,21)/t9-/m0/s1
  • Key:QEFZCKUXGLDPPT-VIFPVBQESA-N

SH-I-048A (SH-i-048A) is a benzodiazepine derivative related in structure to compounds such as flubromazepam and meclonazepam. SH-I-048A is described as a non subtype selective superagonist at the benzodiazepine site of GABAA receptors,[1] with a binding affinity of 0.77 nM at the α1 subtype, 0.17 nM at α2, 0.38 nM at α3 and 0.11 nM at α5.[2] It has been used to study the functional differences between the different subtypes of the GABAA receptor.[3][4]

See also

References

  1. ^ Obradović AL, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM (2014). "Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects". Brain Research. 1554: 36–48. doi:10.1016/j.brainres.2014.01.036. PMC 3996760. PMID 24472579.
  2. ^ Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, et al. (2015). "A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model". International Journal of Medicinal Chemistry. 2015: 430248. doi:10.1155/2015/430248. PMC 4657098. PMID 26682068.
  3. ^ Obradović LA, Joksimović S, Poe MM, Timić T, Cook JM, Savić MM (June 2014). "Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats". Acta Veterinaria. 64 (2): 189–99. doi:10.2478/acve-2014-0018.
  4. ^ Elgarf AA, Siebert DC, Steudle F, Draxler A, Li G, Huang S, et al. (August 2018). "Different Benzodiazepines Bind With Distinct Binding Modes to GABAA Receptors". ACS Chemical Biology. 13 (8): 2033–2039. doi:10.1021/acschembio.8b00144. PMC 6102643. PMID 29767950.
This page was last edited on 21 March 2024, at 19:04
Basis of this page is in Wikipedia. Text is available under the CC BY-SA 3.0 Unported License. Non-text media are available under their specified licenses. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. WIKI 2 is an independent company and has no affiliation with Wikimedia Foundation.
Contact WIKI 2
Introduction
Terms of Service
Privacy Policy