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From Wikipedia, the free encyclopedia

Niflumic acid
Niflumic acid.png
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Pharmacokinetic data
Biological half-life 2.5 hr[1]
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.022.289
Chemical and physical data
Formula C13H9F3N2O2
Molar mass 282.21797 g/mol
3D model (JSmol)
Melting point 204 °C (399 °F)
 NYesY (what is this?)  (verify)

Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor of cyclooxygenase-2. In experimental biology, it has been employed to inhibit chloride channels.[2] It has also been reported to act on GABA-A[3] and NMDA channels[4] and to block T-type calcium channels.[5]

References

  1. ^ "Half life". Drug Bank. Retrieved 15 July 2011. 
  2. ^ Knauf, Philip A.; Mann, Nancy A (1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". J. Gen. Physiol. 83: 703–725. PMC 2215658Freely accessible. PMID 6736917. doi:10.1085/jgp.83.5.703. 
  3. ^ Sinkkonen ST et al. (2003): Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug, Mol Pharmacol, p. 753-63. PMID 12920213
  4. ^ Lerma J., Martin d.R. (1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation". Mol. Pharmacol. 41 (2): 217–222. PMID 1371581. 
  5. ^ Balderas E et al. (2012): Niflumic acid blocks native and recombinant T-type channels, J Cell Physiol, p. 2542-55. PMID 21898399



This page was last edited on 27 August 2017, at 13:37.
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