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From Wikipedia, the free encyclopedia

PWZ-029
PWZ-029.svg
Identifiers
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
Formula C14H14ClN3O2
Molar mass 291.732 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

PWZ-029 is a benzodiazepine derivative drug with nootropic effects developed by WiSys,[1] It acts as a subtype-selective, mixed agonist-inverse agonist at the benzodiazepine binding site on the GABAA receptor, acting as a partial inverse agonist at the α5 subtype and a weak partial agonist at the α3 subtype. This gives it a mixed pharmacological profile, producing at low doses memory-enhancing effects but with no convulsant or anxiogenic effects or muscle weakness, although at higher doses it produces some sedative effects.[2]

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Transcription

See also

References

  1. ^ US Patent application US2006/258643 A1
  2. ^ Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM. PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. Brain Research. 2008 May 7;1208:150-9. doi:10.1016/j.brainres.2008.02.020 PMID 18394590


This page was last edited on 22 May 2017, at 18:53.
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