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From Wikipedia, the free encyclopedia

Divaplon
Clinical data
ATC code
  • none
Identifiers
  • (6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidin-2-yl)-phenylmethanone
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H17N3O2
Molar mass295.342 g·mol−1
3D model (JSmol)
  • CCC1=C(N2C=C(N=C2N=C1OC)C(=O)C3=CC=CC=C3)C
  • InChI=1S/C17H17N3O2/c1-4-13-11(2)20-10-14(18-17(20)19-16(13)22-3)15(21)12-8-6-5-7-9-12/h5-10H,4H2,1-3H3
  • Key:NRJVHCSYLGLURI-UHFFFAOYSA-N
  (verify)

Divaplon (RU-32698) is a nonbenzodiazepine, anxiolytic and anticonvulsant drug from the imidazopyrimidine family of drugs. It acts as a partial agonist at the "benzodiazepine site" of the GABAA receptor in the brain.[1][2][3]

References

  1. ^ Feely M, Boyland P, Picardo A, Cox A, Gent JP (May 1989). "Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812". European Journal of Pharmacology. 164 (2): 377–80. doi:10.1016/0014-2999(89)90482-2. PMID 2759183.
  2. ^ Sanger DJ, Joly D, Perrault G (September 1995). "Benzodiazepine (omega) receptor partial agonists and the acquisition of conditioned fear in mice". Psychopharmacology. 121 (1): 104–8. doi:10.1007/BF02245596. PMID 8539334. S2CID 32627339.
  3. ^ Pellón R, Ruíz A, Lamas E, Rodríguez C (February 2007). "Pharmacological analysis of the effects of benzodiazepines on punished schedule-induced polydipsia in rats". Behavioural Pharmacology. 18 (1): 81–7. doi:10.1097/FBP.0b013e3280143212. PMID 17218801. S2CID 40188048.
This page was last edited on 25 March 2024, at 07:45
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