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Ro07-5220

From Wikipedia, the free encyclopedia

Ro07-5220
Legal status
Legal status
Identifiers
  • 7-chloro-5-(2,6-dichlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H11Cl3N2O
Molar mass353.63 g·mol−1
3D model (JSmol)
  • CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=C(C=CC=C3Cl)Cl
  • InChI=1S/C16H11Cl3N2O/c1-21-13-6-5-9(17)7-10(13)16(20-8-14(21)22)15-11(18)3-2-4-12(15)19/h2-7H,8H2,1H3
  • Key:OTQXKRRISJPTFS-UHFFFAOYSA-N

Ro07-5220 (6'-Chlorodiclazepam) is a benzodiazepine derivative with sedative, anxiolytic, anticonvulsant and muscle relaxant effects,[1][2][3] which has been sold as a designer drug.[4]

See also

References

  1. ^ Fryer RI, Leimgruber W, Trybulski EJ (September 1982). "Quinazolines and 1,4-benzodiazepines. 90. Structure-activity relationship between substituted 2-amino-N-(2-benzoyl-4-chlorophenyl)acetamides and 1,4-benzodiazepinones". Journal of Medicinal Chemistry. 25 (9): 1050–5. doi:10.1021/jm00351a009. PMID 6127410.
  2. ^ Maddalena DJ, Johnston GA (February 1995). "Prediction of receptor properties and binding affinity of ligands to benzodiazepine/GABAA receptors using artificial neural networks". Journal of Medicinal Chemistry. 38 (4): 715–24. doi:10.1021/jm00004a017. PMID 7861419.
  3. ^ Richter L, de Graaf C, Sieghart W, Varagic Z, Mörzinger M, de Esch IJ, Ecker GF, Ernst M (March 2012). "Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands". Nature Chemical Biology. 8 (5): 455–64. doi:10.1038/nchembio.917. PMC 3368153. PMID 22446838.
  4. ^ Catalani V, Botha M, Corkery JM, Guirguis A, Vento A, Scherbaum N, Schifano F (July 2021). "The Psychonauts' Benzodiazepines; Quantitative Structure-Activity Relationship (QSAR) Analysis and Docking Prediction of Their Biological Activity". Pharmaceuticals (Basel, Switzerland). 14 (8): 720. doi:10.3390/ph14080720. PMC 8398354. PMID 34451817.


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This page was last edited on 4 February 2024, at 01:41
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