Keratin 10

KRT10

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
4F1Z, 3ASW, 4ZRY

Identifiers

Aliases

KRT10, BCIE, BIE, CK10, EHK, K10, KPP, keratin 10

External IDs

OMIM: 148080 GeneCards: KRT10

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q21.2	Start	40,818,117 bp^[1]
Band	17q21.2	End	40,822,614 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

vulva

nipple

human penis

skin of abdomen

gums

sperm

parotid gland

palpebral conjunctiva

vagina

amniotic fluid

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	structural molecule activity structural constituent of skin epidermis protein heterodimerization activity protein binding
Cellular component	cytoplasm extracellular exosome intermediate filament membrane nucleus extracellular space cytosol cornified envelope extracellular region cell surface
Biological process	keratinocyte differentiation keratinization cornification peptide cross-linking positive regulation of epidermis development protein heterotetramerization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3858


n/a

Ensembl


ENSG00000186395


n/a

UniProt


P13645


n/a

RefSeq (mRNA)


NM_000421 NM_001379366


n/a

RefSeq (protein)


NP_000412 NP_001366295


n/a

Location (UCSC)

Chr 17: 40.82 – 40.82 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene.^[3]^[4]^[5] Keratin 10 is a type I keratin.

Function

Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.^[5]

Interactions

Keratin 10 has been shown to interact with AKT1.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186395 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lessin SR, Huebner K, Isobe M, Croce CM, Steinert PM (Jan 1989). "Chromosomal mapping of human keratin genes: evidence of non-linkage". J Invest Dermatol. 91 (6): 572–8. doi:10.1111/1523-1747.ep12477087. PMID 2461420.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)".
^ Paramio, J M; Segrelles C; Ruiz S; Jorcano J L (Nov 2001). "Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest". Mol. Cell. Biol. United States. 21 (21): 7449–59. doi:10.1128/MCB.21.21.7449-7459.2001. ISSN 0270-7306. PMC 99917. PMID 11585925.

Yang JM, Nam K, Kim SW, et al. (1999). "Arginine in the beginning of the 1A rod domain of the keratin 10 gene is the hot spot for the mutation in epidermolytic hyperkeratosis". J. Dermatol. Sci. 19 (2): 126–33. doi:10.1016/S0923-1811(98)00055-3. PMID 10098704.
Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
Korge BP, Gan SQ, McBride OW, et al. (1992). "Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops". Proc. Natl. Acad. Sci. U.S.A. 89 (3): 910–4. Bibcode:1992PNAS...89..910K. doi:10.1073/pnas.89.3.910. PMC 48354. PMID 1371013.
Tkachenko AV, Buchman VL, Bliskovsky VV, et al. (1992). "Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats". Gene. 116 (2): 245–51. doi:10.1016/0378-1119(92)90521-P. PMID 1378806.
Rothnagel JA, Dominey AM, Dempsey LD, et al. (1992). "Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis". Science. 257 (5073): 1128–30. Bibcode:1992Sci...257.1128R. doi:10.1126/science.257.5073.1128. PMID 1380725. S2CID 30648935.
Cheng J, Syder AJ, Yu QC, et al. (1992). "The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes". Cell. 70 (5): 811–9. doi:10.1016/0092-8674(92)90314-3. PMID 1381287. S2CID 31906051.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Nazzaro V, Ermacora E, Santucci B, Caputo R (1990). "Epidermolytic hyperkeratosis: generalized form in children from parents with systematized linear form". Br. J. Dermatol. 122 (3): 417–22. doi:10.1111/j.1365-2133.1990.tb08292.x. PMID 2182100. S2CID 9344745.
Darmon MY, Sémat A, Darmon MC, Vasseur M (1988). "Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression". Mol. Biol. Rep. 12 (4): 277–83. doi:10.1007/BF00444680. PMID 2448602. S2CID 4322605.
Zhou XM, Idler WW, Steven AC, et al. (1988). "The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences". J. Biol. Chem. 263 (30): 15584–9. doi:10.1016/S0021-9258(19)37628-8. PMID 2459124.
Rieger M, Franke WW (1989). "Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10". J. Mol. Biol. 204 (4): 841–56. doi:10.1016/0022-2836(88)90045-9. PMID 2464696.
van Dongen GA, Braakhuis BJ, Leyva A, et al. (1989). "Anti-tumor and differentiation-inducing activity of N,N-dimethylformamide (DMF) in head-and-neck cancer xenografts". Int. J. Cancer. 43 (2): 285–92. doi:10.1002/ijc.2910430221. PMID 2465278. S2CID 22052183.
Rogaev EI, Rogaeva EA, Ginter EK, et al. (1994). "Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes". Nat. Genet. 5 (2): 158–62. doi:10.1038/ng1093-158. PMID 7504553. S2CID 9295678.
Rothnagel JA, Longley MA, Holder RA, et al. (1994). "Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing". J. Invest. Dermatol. 102 (1): 13–6. doi:10.1111/1523-1747.ep12371723. PMID 7507150.
McLean WH, Eady RA, Dopping-Hepenstal PJ, et al. (1994). "Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE)". J. Invest. Dermatol. 102 (1): 24–30. doi:10.1111/1523-1747.ep12371726. PMID 7507152.
Chipev CC, Yang JM, DiGiovanna JJ, et al. (1994). "Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis". Am. J. Hum. Genet. 54 (2): 179–90. PMC 1918158. PMID 7508181.
Rothnagel JA, Fisher MP, Axtell SM, et al. (1994). "A mutational hot spot in keratin 10 (KRT 10) in patients with epidermolytic hyperkeratosis" (PDF). Hum. Mol. Genet. 2 (12): 2147–50. doi:10.1093/hmg/2.12.2147. PMID 7509230.
Syder AJ, Yu QC, Paller AS, et al. (1994). "Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity". J. Clin. Invest. 93 (4): 1533–42. doi:10.1172/JCI117132. PMC 294170. PMID 7512983.
Huber M, Scaletta C, Benathan M, et al. (1994). "Abnormal keratin 1 and 10 cytoskeleton in cultured keratinocytes from epidermolytic hyperkeratosis caused by keratin 10 mutations". J. Invest. Dermatol. 102 (5): 691–4. doi:10.1111/1523-1747.ep12374270. PMID 7513736.

Proteins of the cytoskeleton

Human

Microfilaments
and ABPs

Myofilament

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
and MAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal: DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3