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Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1gene.[5][6][7]
This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.[7]
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Gene Music using Protein Sequence of STAT3 "SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (ACU"
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S (Dec 2001). "Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients". Gene. 281 (1–2): 103–13. doi:10.1016/S0378-1119(01)00787-9. PMID11750132.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID12665801. S2CID23783563.
Saito Y, Doi K, Yamagishi N, et al. (2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochem. Biophys. Res. Commun. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. PMID14733918.
Campbell IG, Phillips WA, Choong DY (2006). "Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers". Clin. Cancer Res. 12 (12): 3713–5. doi:10.1158/1078-0432.CCR-06-0800. PMID16778097. S2CID24551435.
Pérez-González A, Rodriguez A, Huarte M, et al. (2007). "hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator". J. Mol. Biol. 362 (5): 887–900. doi:10.1016/j.jmb.2006.07.085. PMID16950395.
Liu JF, Wang ZX, Wang XQ, et al. (2006). "Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74". Biochem. Biophys. Res. Commun. 349 (3): 1125–9. doi:10.1016/j.bbrc.2006.08.161. PMID16970917.
Kang HC, Kim IJ, Kim K, et al. (2007). "km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers". Cancer Genet. Cytogenet. 175 (2): 173–4. doi:10.1016/j.cancergencyto.2007.02.004. PMID17556076.
Wanschers B, van de Vorstenbosch R, Fransen J, et al. (2008). "Rab6 family proteins interact with the dynein light chain protein DYNLRB1". Cell Motil. Cytoskeleton. 65 (3): 183–96. doi:10.1002/cm.20254. PMID18044744.
External links
Overview of all the structural information available in the PDB for UniProt: Q9NP97 (Dynein light chain roadblock-type 1) at the PDBe-KB.