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The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ruhrberg C, Williamson JA, Maatta A, Watt FM (Jun 1998). "The periplakin gene maps to 16p13.3 in human and 16A-B1 in mouse". Genomics. 49 (1): 157–9. doi:10.1006/geno.1997.5206. PMID9570964.
^Aho S, McLean WH, Li K, Uitto J (Jun 1998). "cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes". Genomics. 48 (2): 242–7. doi:10.1006/geno.1997.5188. PMID9521878.
Aho S, Rothenberger K, Tan EM, et al. (1999). "Human periplakin: genomic organization in a clonally unstable region of chromosome 16p with an abundance of repetitive sequence elements". Genomics. 56 (2): 160–8. doi:10.1006/geno.1998.5704. PMID10051401.
van den Heuvel AP, de Vries-Smits AM, van Weeren PC, et al. (2003). "Binding of protein kinase B to the plakin family member periplakin". J. Cell Sci. 115 (Pt 20): 3957–66. doi:10.1242/jcs.00069. PMID12244133. S2CID12136252.
Kazerounian S, Uitto J, Aho S (2003). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol. 11 (5): 428–38. doi:10.1034/j.1600-0625.2002.110506.x. PMID12366696. S2CID25735126.
Karashima T, Watt FM (2003). "Interaction of periplakin and envoplakin with intermediate filaments". J. Cell Sci. 115 (Pt 24): 5027–37. doi:10.1242/jcs.00191. PMID12432088. S2CID22383123.
This page was last edited on 24 December 2023, at 07:37