KIF20A

KIF20A

Identifiers

KIF20A, MKLP2, RAB6KIFL, kinesin family member 20A, RCM6

External IDs

OMIM: 605664 MGI: 1201682 HomoloGene: 38093 GeneCards: KIF20A

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q31.2	Start	138,178,719 bp^[1]
Band	5q31.2	End	138,187,723 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18 B1\|18 18.69 cM	Start	34,757,666 bp^[2]
Band	18 B1\|18 18.69 cM	End	34,766,330 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

embryo

secondary oocyte

ganglionic eminence

stromal cell of endometrium

bone marrow

cancellous bone

bone marrow cells

thymus

sperm

Top expressed in

spermatocyte

primitive streak

abdominal wall

maxillary prominence

somite

spermatid

secondary oocyte

hand

yolk sac

morula

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	microtubule motor activity nucleotide binding transporter activity microtubule binding ATPase activity protein binding ATP binding protein kinase binding
Cellular component	cytoplasm Golgi apparatus kinesin complex spindle midbody microtubule cytoskeleton nucleoplasm cleavage furrow intercellular bridge nucleus
Biological process	mitotic cytokinesis microtubule-based movement microtubule bundle formation protein transport septum digestion after cytokinesis vesicle-mediated transport cytokinesis regulation of cytokinesis midbody abscission
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10112


19348

Ensembl


ENSG00000112984


ENSMUSG00000003779

UniProt


O95235


P97329

RefSeq (mRNA)


NM_005733


NM_001166406 NM_001166407 NM_009004

RefSeq (protein)


NP_005724


NP_001159878 NP_001159879 NP_033030

Location (UCSC)

Chr 5: 138.18 – 138.19 Mb

Chr 18: 34.76 – 34.77 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Kinesin-like protein KIF20A is a protein that in humans is encoded by the KIF20A gene.^[5]^[6]^[7]

Interactions

KIF20A has been shown to interact with RAB6A.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112984 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003779 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc Natl Acad Sci U S A. 98 (13): 7004–11. Bibcode:2001PNAS...98.7004M. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
^ Lai F, Fernald AA, Zhao N, Le Beau MM (July 2000). "cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene". Gene. 248 (1–2): 117–25. doi:10.1016/S0378-1119(00)00135-9. PMID 10806357.
^ "Entrez Gene: KIF20A kinesin family member 20A".
^ Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (January 1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6". Science. 279 (5350): 580–5. Bibcode:1998Sci...279..580E. doi:10.1126/science.279.5350.580. PMID 9438855.
^ Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Mol. Biol. Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.

Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6". Science. 279 (5350): 580–5. Bibcode:1998Sci...279..580E. doi:10.1126/science.279.5350.580. PMID 9438855.
Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H (1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. doi:10.1182/blood.V93.10.3418.410k23_3418_3431. PMID 10233894.
Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". J. Cell Sci. 113 (15): 2725–35. doi:10.1242/jcs.113.15.2725. PMID 10893188.
Hill E, Clarke M, Barr FA (2000). "The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis". EMBO J. 19 (21): 5711–9. doi:10.1093/emboj/19.21.5711. PMC 305783. PMID 11060022.
Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (2001). "Alternative Splicing of the Human Rab6A Gene Generates Two Close but Functionally Different Isoforms". Mol. Biol. Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Nagura M, Nagao Y, Takita J, Igarashi T, LeGuern E, Hayashi Y (2003). "The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C". Int. J. Mol. Med. 11 (1): 45–7. doi:10.3892/ijmm.11.1.45. PMID 12469216.
Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA (2003). "Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis". J. Cell Biol. 162 (5): 863–75. doi:10.1083/jcb.200306009. PMC 2172827. PMID 12939256.
Gruneberg U, Neef R, Honda R, Nigg EA, Barr FA (2004). "Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2". J. Cell Biol. 166 (2): 167–72. doi:10.1083/jcb.200403084. PMC 2172317. PMID 15263015.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Taniuchi K, Nakagawa H, Nakamura T, Eguchi H, Ohigashi H, Ishikawa O, Katagiri T, Nakamura Y (2005). "Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell". Cancer Res. 65 (1): 105–12. doi:10.1158/0008-5472.105.65.1. PMID 15665285. S2CID 16616574.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

KIF20A human gene location in the UCSC Genome Browser.
KIF20A human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 30 January 2023, at 04:37

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Interactions

References

Further reading

External links