A nonsteroidal compound is a drug that is not a steroid nor a steroid derivative.[1][2] Nonsteroidal anti-inflammatory drugs (NSAIDs) are distinguished from corticosteroids as a class of anti-inflammatory agents.[3]
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List of nonsteroidal steroid receptor modulators
Examples include the following:[1][2]
- Estrogens: benzestrol, bifluranol, estrobin (DBE), diethylstilbestrol (stilbestrol), dienestrol, erteberel, fosfestrol, hexestrol (dihydroxystilbestrol), methallenestril, methestrol, methestrol dipropionate, paroxypropione, prinaberel, and triphenylethylene, as well as many xenoestrogens
- SERMsTooltip Selective estrogen receptor modulators: acolbifene, afimoxifene, arzoxifene, bazedoxifene, broparestrol, chlorotrianisene, clomifene, clomifenoxide, cyclofenil, droloxifene, enclomifene, endoxifen, ethamoxytriphetol, fispemifene, idoxifene, lasofoxifene, levormeloxifene, miproxifene, nafoxidine, nitromifene, ormeloxifene, ospemifene, panomifene, pipendoxifene, raloxifene, tamoxifen, toremifene, trioxifene, zindoxifene, zuclomifene
- Antiandrogens: apalutamide, bicalutamide, cimetidine, darolutamide, DIMP, enzalutamide, EPI-001, EPI-506, flutamide, hydroxyflutamide, inocoterone, inocoterone acetate, nilutamide, RU-58642, RU-58841, and topilutamide
- SARMsTooltip Selective androgen receptor modulators: AC-262,356, acetothiolutamide, andarine, BMS-564,929, enobosarm (ostarine), LGD-2226, LGD-3303, LGD-4033, S-23, and S-40503
- Aromatase inhibitors: anastrozole, aminoglutethimide, fadrozole, finrozole, letrozole, liarozole, norendoxifen, rogletimide (pyridoglutethimide), vorozole
- Other steroidogenesis inhibitors: aminoglutethimide, ketoconazole, orteronel, seviteronel, others
- Miscellaneous: tanaproget (progestogen), finerenone (antimineralocorticoid), esaxerenone (antimineralocorticoid), apararenone (antimineralocorticoid), AZD5423 (glucocorticoid), mapracorat (SGRMTooltip Selective glucocorticoid receptor modulator)
See also
References
- ^ a b Edward J. Pavlik (6 December 2012). Estrogens, Progestins, and Their Antagonists: Health Issues. Springer Science & Business Media. pp. 166–. ISBN 978-1-4612-4096-9.
- ^ a b Thomas Nogrady Professor of Medicinal Chemistry Concordia University (Emeritus); Donald F. Weaver Canada Research Chair and Professor of Medicine and Chemistry Dalhousie University (27 July 2005). Medicinal Chemistry : A Molecular and Biochemical Approach: A Molecular and Biochemical Approach. Oxford University Press, USA. pp. 322–. ISBN 978-0-19-802645-7.
- ^ Buer JK (Oct 2014). "Origins and impact of the term 'NSAID'". Inflammopharmacology. 22 (5): 263–7. doi:10.1007/s10787-014-0211-2. hdl:10852/45403. PMID 25064056. S2CID 16777111.
Further reading
- Miquel JF, Gilbert J (1988). "A chemical classification of nonsteroidal antagonists of sex-steroid hormone action". J. Steroid Biochem. 31 (4B): 525–44. doi:10.1016/0022-4731(88)90004-0. PMID 3059055.
- Buijsman, Rogier; Hermkens, Pedro; Rijn, Rachel; Stock, H.; Teerhuis, N. (2005). "Non-Steroidal Steroid Receptor Modulators". Current Medicinal Chemistry. 12 (9): 1017–1075. doi:10.2174/0929867053764671. ISSN 0929-8673. PMID 16821162.
- Hermkens PH, Kamp S, Lusher S, Veeneman GH (2006). "Non-steroidal steroid receptor modulators". IDrugs. 9 (7): 488–94. doi:10.2174/0929867053764671. PMID 16821162.
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This page was last edited on 21 July 2023, at 23:18