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Nivacortol

From Wikipedia, the free encyclopedia

Nivacortol
Clinical data
Other namesNivazol; Nivazole; WIN-27914; Novozola; NEBO-174; 2'-(4-Fluorophenyl)-2'-H-pregna-2,4-dien-20-yno(3,2-c)pyrazol-17-ol
Drug classCorticosteroid; Glucocorticoid
Identifiers
  • (1R,3aS,3bR,10aR,10bS,12aS)-1-Ethynyl-7-(4-fluorophenyl)-10a,12a-dimethyl-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-ol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard100.041.987 Edit this at Wikidata
Chemical and physical data
FormulaC28H31FN2O
Molar mass430.567 g·mol−1
3D model (JSmol)
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC5=C(C[C@]34C)C=NN5C6=CC=C(C=C6)F
  • InChI=InChI=1S/C28H31FN2O/c1-4-28(32)14-12-24-22-10-5-19-15-25-18(16-26(19,2)23(22)11-13-27(24,28)3)17-30-31(25)21-8-6-20(29)7-9-21/h1,6-9,15,17,22-24,32H,5,10-14,16H2,2-3H3/t22-,23+,24+,26+,27+,28+/m1/s1
  • Key:ZQLOAGFNRKBEAJ-BDPSOKNUSA-N

Nivacortol (developmental code names WIN-27914 and NEBO-174; also known as nivazol and nivazole) is a synthetic glucocorticoid corticosteroid which was never marketed.[1][2][3][4]

References

  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 881–882. ISBN 978-1-4757-2085-3.
  2. ^ "Nivazole". AdisInsight. Springer Nature Switzerland AG.
  3. ^ Elguero J, Silva AM, Tome AC (2011). "Five-Membered Heterocycles: 1,2-Azoles, Part 1. Pyrazoles". In Alvarez-Builla J, Vaquero JJ, Barluenga J (eds.). Modern Heterocyclic Chemistry. Vol. 1. John Wiley & Sons. pp. 649–. ISBN 978-3-527-33201-4.
  4. ^ Honour JW, Sudan HL, Lovell G (August 1986). "The determination of nivacortol in plasma using HPLC". Biomedical Chromatography. 1 (4): 151–154. doi:10.1002/bmc.1130010404. PMID 3506827.
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This page was last edited on 8 December 2023, at 18:15
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