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Cortivazol

From Wikipedia, the free encyclopedia

Cortivazol
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • (11β,16α)-21-(Acetyloxy)-11,17-dihydroxy-6,16-dimethyl-2'-phenyl-2'H-pregna-2,4,6-trieno[3,2-c]pyrazol-20-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.012.887 Edit this at Wikidata
Chemical and physical data
FormulaC32H38N2O5
Molar mass530.665 g·mol−1
3D model (JSmol)
  • O=C(OCC(=O)[C@@]4(O)[C@H](C)C[C@H]5[C@@H]6/C=C(\C3=C\c1c(cnn1c2ccccc2)C[C@@]3([C@H]6[C@@H](O)C[C@]45C)C)C)C
  • InChI=1S/C32H38N2O5/c1-18-11-23-25-12-19(2)32(38,28(37)17-39-20(3)35)31(25,5)15-27(36)29(23)30(4)14-21-16-33-34(26(21)13-24(18)30)22-9-7-6-8-10-22/h6-11,13,16,19,23,25,27,29,36,38H,12,14-15,17H2,1-5H3/t19-,23+,25+,27+,29-,30+,31+,32+/m1/s1 checkY
  • Key:RKHQGWMMUURILY-UHRZLXHJSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Cortivazol is a high-affinity agonist ligand for the glucocorticoid receptor and consequently is classified as a glucocorticoid.[1]

It is sometimes abbreviated "CVZ".[2]

References

  1. ^ Schlechte JA, Simons SS, Lewis DA, Thompson EB (October 1985). "[3H]cortivazol: a unique high affinity ligand for the glucocorticoid receptor". Endocrinology. 117 (4): 1355–62. doi:10.1210/endo-117-4-1355. PMID 4029081.
  2. ^ Yoshikawa N, Yamamoto K, Shimizu N, Yamada S, Morimoto C, Tanaka H (May 2005). "The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor". Mol. Endocrinol. 19 (5): 1110–24. doi:10.1210/me.2004-0264. PMID 15677712.[permanent dead link]

External links

Cortivazol at the U.S. National Library of Medicine Medical Subject Headings (MeSH)



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This page was last edited on 25 March 2024, at 07:56
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