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Indenolol

From Wikipedia, the free encyclopedia

Indenolol
Names
IUPAC name
1-(1H-Inden-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
DrugBank
EC Number
  • 262-323-5
KEGG
UNII
  • InChI=1S/C15H21NO2/c1-11(2)16-9-13(17)10-18-15-8-4-6-12-5-3-7-14(12)15/h3-4,6-8,11,13,16-17H,5,9-10H2,1-2H3
    Key: MPGBPFMOOXKQRX-UHFFFAOYSA-N
  • InChI=1/C15H21NO2/c1-11(2)16-9-13(17)10-18-15-8-4-6-12-5-3-7-14(12)15/h3-4,6-8,11,13,16-17H,5,9-10H2,1-2H3
    Key: MPGBPFMOOXKQRX-UHFFFAOYAY
  • CC(C)NCC(COC1=CC=CC2=C1C=CC2)O
Properties
C15H21NO2
Molar mass 247.338 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Indenolol is a beta-adrenergic blocker[1] for the treatment of hypertension (high blood pressure). It was investigated in the 1980s,[2] but is not known to be marketed as of 2021.[3] It is a derivative of a phenolic 4-indenol.

References

  1. ^ Ali, I; Gaitonde, VD; Aboul-Enein, HY; Hussain, A (2009). "Chiral separation of beta-adrenergic blockers on CelluCoat column by HPLC". Talanta. 78 (2): 458–63. doi:10.1016/j.talanta.2008.11.043. PMID 19203609.
  2. ^ Trimarco, Bruno; Cuocolo, Alberto; Groothold, Gisela; Ricciardelli, Bruno; De Luca, Nicola; Volpe, Massimo; Veniero, Anna Maria; Condorelli, Mario (1985). "Indenolol: A New Antihypertensive Agent: Efficacy, Toxicity, and Hemodynamic Effects in a Crossover Double-Blind Study with Metoprolol". The Journal of Clinical Pharmacology. 25 (5): 328–336. doi:10.1002/j.1552-4604.1985.tb02850.x. PMID 4031109. S2CID 22844379.
  3. ^ DrugBank DB08952 . Accessed 2021-03-18.


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This page was last edited on 4 March 2023, at 03:18
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