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Cetamolol

From Wikipedia, the free encyclopedia

Cetamolol
Names
IUPAC name
2-[2-[3-(tert-Butylamino)-2-hydroxypropoxy]phenoxy]-N-methylacetamide
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
KEGG
UNII
  • InChI=1S/C16H26N2O4/c1-16(2,3)18-9-12(19)10-21-13-7-5-6-8-14(13)22-11-15(20)17-4/h5-8,12,18-19H,9-11H2,1-4H3,(H,17,20)
    Key: UWCBNAVPISMFJZ-UHFFFAOYSA-N
  • CC(C)(C)NCC(COC1=CC=CC=C1OCC(=O)NC)O
Properties
C16H26N2O4
Molar mass 310.394 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Cetamolol is a beta adrenergic antagonist, more specifically a β1-adrenergic blocker.[1]

Synthesis

Cetamolol synthesis:[2][3][4]

References

  1. ^ Klausner, MA; Irwin, C; Mullane, JF; Shand, DG; Leese, PT; Arnold, JD; Wollberg, W; Wagner, NB; Wagner, GS (1988). "Effect of cetamolol on epinephrine-induced hypokalemia". Journal of Clinical Pharmacology. 28 (8): 751–6. doi:10.1002/j.1552-4604.1988.tb03210.x. PMID 2905711. S2CID 30767741.
  2. ^ GB 1458392, "Optically-active 1-aryloxy-2,3-epoxypropane derviatives", published 1976-12-15, assigned to Imperial Chemical Industries Ltd. 
  3. ^ BE 767781, "Alkanolamines", published 1971-11-29, assigned to Imperial Chemical Industries Ltd. 
  4. ^ D. J. Lecount, C. J. Squire, U.S. Patent 4,059,622 (1977 to ICI).
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This page was last edited on 19 October 2023, at 10:35
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