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Tertatolol

From Wikipedia, the free encyclopedia

Tertatolol
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • (±)-1-(tert-Butylamino)-3-(3,4-dihydro-2H-thiochromen-8-yloxy)propan-2-ol
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard100.073.179 Edit this at Wikidata
Chemical and physical data
FormulaC16H25NO2S
Molar mass295.44 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • CC(C)(C)NCC(COC1=CC=CC2=C1SCCC2)O
  • InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 ☒N
  • Key:HTWFXPCUFWKXOP-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Tertatolol (Artex, Artexal, Prenalex) is a medication in the class of beta blockers, used in the treatment of high blood pressure. It was discovered by the French pharmaceutical company Servier and is marketed in Europe.[1]

Tertatolol has also been shown to act as a serotonin 5-HT1A and 5-HT1B receptor antagonist, similarly to propranolol and pindolol.[2][3][4]

See also

References

  1. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
  2. ^ Langlois M, Brémont B, Rousselle D, Gaudy F (January 1993). "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors". European Journal of Pharmacology. 244 (1): 77–87. doi:10.1016/0922-4106(93)90061-d. PMID 8093601.
  3. ^ Jolas T, Haj-Dahmane S, Lanfumey L, Fattaccini CM, Kidd EJ, Adrien J, et al. (May 1993). "(-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain". Naunyn-Schmiedeberg's Archives of Pharmacology. 347 (5): 453–463. doi:10.1007/bf00166735. PMID 7686633. S2CID 22129922.
  4. ^ van Wijngaarden I, Soudijn W, Tulp MT (1997). "5-HT1A Receptors". In Soudijn W, Olivier B, van Wijngaarden I (eds.). Serotonin Receptors and Their Ligands. Amsterdam: Elsevier. ISBN 0-444-82041-8.
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This page was last edited on 2 December 2023, at 07:04
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