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Triflubazam

From Wikipedia, the free encyclopedia

Triflubazam
Identifiers
  • 1-methyl-5-phenyl-7-(trifluoromethyl)-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H13F3N2O2
Molar mass334.298 g·mol−1
3D model (JSmol)
  • FC(F)(C1=CC(N(C2=CC=CC=C2)C(CC(N3C)=O)=O)=C3C=C1)F
  • InChI=1S/C17H13F3N2O2/c1-21-13-8-7-11(17(18,19)20)9-14(13)22(16(24)10-15(21)23)12-5-3-2-4-6-12/h2-9H,10H2,1H3 checkY
  • Key:DMNPCIKBNDKNTO-UHFFFAOYSA-N checkY
  (verify)

Triflubazam[1] is a drug which is a 1,5-benzodiazepine derivative, related to clobazam.[2] It has sedative and anxiolytic effects, with a long half-life and duration of action.[3][4][5]

See also

References

  1. ^ US 3660381, Karl-Heinz Weber KH, Merz H, K Zeile, Giesemann R, Danneberg P, "5-Aryl-1H-1,5-benzodiazepine-2,4-diones", issued 2 May 1972, assigned to CH Boehringer Sohn AG and Co KG 
  2. ^ Lundbeck Institute (2003). "triflubazam". psychotropics.dk. Retrieved 17 November 2010.
  3. ^ Itil TM, Akpinar S, Fink M, Polvan N, Huque M, Sungurbey K (March 1976). "Controlled clinical and quantitative EEG studies of triflubazam (ORF 8063) in patients with anxiety syndrome". Current Therapeutic Research, Clinical and Experimental. 19 (3): 307–15. PMID 5248.
  4. ^ Csanalosi I, Pereira-Oran J, Case G, et al. (1977). "Triflubazam (ORF 8063), a new benzodiazepine in anxiety neurosis". Current Therapeutic Research. 22: 166–171.
  5. ^ Nicholson AN, Stone BM, Clarke CH (October 1977). "Effect of the 1,5-benzodiazepines, clobazam and triflubazam, on sleep in man". British Journal of Clinical Pharmacology. 4 (5): 567–72. doi:10.1111/j.1365-2125.1977.tb00787.x. PMC 1429140. PMID 20917.


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This page was last edited on 7 December 2023, at 07:39
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