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Clotizolam

From Wikipedia, the free encyclopedia

Clotizolam
Legal status
Legal status
Identifiers
  • 2-Chloro-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H10Cl2N4S
Molar mass349.23 g·mol−1
3D model (JSmol)
Melting point205 °C (401 °F)
  • CC1=NN=C2N1C3=C(C=C(S3)Cl)C(=NC2)C4=CC=CC=C4Cl
  • InChI=1S/C15H10Cl2N4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)16)10-6-12(17)22-15(10)21(8)13/h2-6H,7H2,1H3
  • Key:CHGXYVPOFYZWRH-UHFFFAOYSA-N

Clotizolam (Ro11-1465) is a thienotriazolodiazepine derivative first invented in the 1970s, which in more recent years has been sold as a designer drug. As with other related thienotriazolodiazepines, it produces sedative, anxiolytic, anticonvulsant and muscle relaxant effects,[1] and also acts as an inhibitor of platelet-activating factor (PAF).[2]

See also

References

  1. ^ US 4155913, Hellerbach J, Zeller P, Binder D, Hromatka O, "Thienotriazolodiazepine derivatives", issued 22 May 1979, assigned to Hoffmann La Roche Inc. 
  2. ^ Tahara T, Mikashima H, Terasawa M, Maruyama Y (May 1987). "PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines". Chemical & Pharmaceutical Bulletin. 35 (5): 2119–21. doi:10.1248/cpb.35.2119. PMID 3664818. S2CID 27564672.


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This page was last edited on 13 August 2023, at 08:08
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