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Saripidem

From Wikipedia, the free encyclopedia

Saripidem
Clinical data
ATC code
  • none
Identifiers
  • N-[[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]-N-methylbutanamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H20ClN3O
Molar mass341.84 g·mol−1
3D model (JSmol)
  • O=C(N(C)Cc1c(nc2ccccn12)c3ccc(Cl)cc3)CCC
  • InChI=1S/C19H20ClN3O/c1-3-6-18(24)22(2)13-16-19(14-8-10-15(20)11-9-14)21-17-7-4-5-12-23(16)17/h4-5,7-12H,3,6,13H2,1-2H3 checkY
  • Key:LIFDPEORUVTOCP-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Saripidem is a sedative and anxiolytic drug in the imidazopyridine family, which is related to the better known drugs zolpidem and alpidem.

Saripidem has a similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties, but its chemical structure is quite different from that of the benzodiazepine drugs, and saripidem is described as a nonbenzodiazepine.

The mechanism of action by which saripidem produces its sedative and anxiolytic effects is by modulating the benzodiazepine binding site on GABAA receptors, however unlike many older GABAA agonists, saripidem is highly subtype selective and binds primarily to the ω1 subtype.[1]

References

  1. ^ Sanger DJ (March 1995). "Behavioural effects of novel benzodiazepine (omega) receptor agonists and partial agonists: increases in punished responding and antagonism of the pentylenetetrazole cue". Behavioural Pharmacology. 6 (2): 116–126. doi:10.1097/00008877-199503000-00003. PMID 11224318. S2CID 42888705.
This page was last edited on 25 November 2022, at 01:30
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