Chemical compound
Norwogonin , also known as 5,7,8-trihydroxyflavone (5,7,8-THF ), is a flavone , a naturally occurring flavonoid -like chemical compound which is found in Scutellaria baicalensis (Baikal skullcap).[1] It has been found to act as an agonist of the TrkB , the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known tropoflavin (7,8-DHF).[2]
See also
References
^ Miyasaki Y, Rabenstein JD, Rhea J, Crouch ML, Mocek UM, Kittell PE, et al. (2013). Khan AU (ed.). "Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii" . PLOS ONE . 8 (4): e61594. Bibcode :2013PLoSO...861594M . doi :10.1371/journal.pone.0061594 . PMC 3632535 . PMID 23630600 .
^ Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al. (December 2010). "A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect" . Journal of Medicinal Chemistry . 53 (23): 8274–86. doi :10.1021/jm101206p . PMC 3150605 . PMID 21073191 .
Aglycones
Monohydroxyflavone Dihydroxyflavones Trihydroxyflavones Tetrahydroxyflavones Pentahydroxyflavones O-methylated flavones
Glycosides
of apigenin of baicalein of hypolaetin
Hypolaetin 8-glucoside
Hypolaetin 8-glucuronide
of luteolin
Acetylated
Artocarpetin A
Artoindonesianin P
Sulfated glycosides Polymers Drugs
Angiopoietin
Kinase inhibitors: Altiratinib
CE-245677
Rebastinib
CNTF EGF (ErbB)
FGF
FGFR1 FGFR2
Agonists: Ersofermin
FGF (1 , 2 (bFGF) , 3 , 4 , 5 , 6 , 7 (KGF ), 8 , 9 , 10 (KGF2) , 17 , 18 , 22 )
Palifermin
Repifermin
Selpercatinib
Sprifermin
Trafermin
Antibodies: Aprutumab
Aprutumab ixadotin
FGFR3 FGFR4 Unsorted
HGF (c-Met) IGF
IGF-1
Kinase inhibitors: BMS-754807
Linsitinib
NVP-ADW742
NVP-AEW541
OSl-906
IGF-2
Antibodies: Dusigitumab
Xentuzumab (against IGF-1 and IGF-2)
Others
Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1)
Trofinetide
LNGF (p75NTR )
Aptamers: Against NGF: RBM-004
Decoy receptors: LEVI-04 (p75<sup>NTR</sup>-Fc)
PDGF RET (GFL)
SCF (c-Kit) TGFβ Trk
TrkA
Negative allosteric modulators: VM-902A
Aptamers: Against NGF: RBM-004
Decoy receptors: ReN-1820 (TrkAd5)
TrkB
Agonists: 3,7-DHF
3,7,8,2'-THF
4'-DMA-7,8-DHF
7,3'-DHF
7,8-DHF
7,8,2'-THF
7,8,3'-THF
Amitriptyline
BDNF
BNN-20
Deoxygedunin
Deprenyl
Diosmetin
DMAQ-B1
HIOC
LM22A-4
N-Acetylserotonin
NT-3
NT-4
Norwogonin (5,7,8-THF)
R7
R13
TDP6
TrkC
VEGF Others
Additional growth factors: Adrenomedullin
Colony-stimulating factors (see here instead)
Connective tissue growth factor (CTGF)
Ephrins (A1 , A2 , A3 , A4 , A5 , B1 , B2 , B3 )
Erythropoietin (see here instead)
Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
Glia maturation factor (GMF)
Hepatoma-derived growth factor (HDGF)
Interleukins /T-cell growth factors (see here instead)
Leukemia inhibitory factor (LIF)
Macrophage-stimulating protein (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migration-stimulating factor (MSF; PRG4)
Oncomodulin
Pituitary adenylate cyclase-activating peptide (PACAP)
Pleiotrophin
Renalase
Thrombopoietin (see here instead)
Wnt signaling proteins
Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)
This page was last edited on 26 April 2023, at 21:18