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| Names | |
|---|---|
| IUPAC name
3′,4′,5,5′,7-Pentahydroxyflavone
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| Systematic IUPAC name
5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one | |
| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| ECHA InfoCard | 100.237.320 |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C15H10O7 | |
| Molar mass | 302.23 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Tricetin is a flavone, a type of flavonoid. It is a rare aglycone found in the pollen of members of the Myrtaceae, subfamily Leptospermoideae, such as Eucalyptus globulus.[1] This compound shows anticancer effects on human breast adenocarcinoma MCF-7 cells.[2] Moreover. a potent anti-inflammatory effect of tricetin has also been demonstrated in a model of acute pancreatitis.[3] This observation was explained by the compound's radical scavenging effects, its inhibitory effect on the DNA damage sensor enzyme poly (ADP-ribose) polymerase-1 (PARP1) and PARP1-mediated cell death and suppression of inflammatory gene expression.
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Transcription
See also
- Tricin synthase produces tricin or tricetin 3′,5′-dimethyl ether
- Tricetin 3′,4′,5′-O-trimethyltransferase
References
- ^ Campos, Maria G.; Webby, Rosemary F.; Markham, Kenneth R. (2002). "The unique occurrence of the flavone aglycone tricetin in Myrtaceae pollen". Zeitschrift für Naturforschung C. 57 (9–10): 944–946. doi:10.1515/znc-2002-9-1031. PMID 12440738. S2CID 29128828.
- ^ Hsu, Ya-Ling; Uen, Yih-Huei; Chen, Yi; Liang, Hsin-Lin; Kuo, Po-Lin (2009). "Tricetin, a dietary flavonoid, inhibits proliferation of human breast adenocarcinoma MCF-7 cells by blocking cell cycle progression and inducing apoptosis". Journal of Agricultural and Food Chemistry. 57 (18): 8688–8695. doi:10.1021/jf901053x. PMID 19705844. S2CID 19856762.
- ^ Nagy-Pénzes, Máté; Hajnády, Zoltán; Regdon, Zsolt; Demény, Máté Á; Kovács, Katalin; El-Hamoly, Tarek; Maléth, József; Hegyi, Péter; Hegedűs, Csaba; Virág, László (June 2022). "Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling". Biomedicines. 10 (6): 1371. doi:10.3390/biomedicines10061371. ISSN 2227-9059. PMC 9219693. PMID 35740393.
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This page was last edited on 7 May 2023, at 20:53