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Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1gene.[5][6]
Function
This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]
Ehrenborg E, Larsson C, Stern I, et al. (1992). "Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7". Genomics. 12 (3): 497–502. doi:10.1016/0888-7543(92)90440-4. PMID1373120.
Ekstrand J, Ehrenborg E, Stern I, et al. (1990). "The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12". Genomics. 6 (3): 413–8. doi:10.1016/0888-7543(90)90470-F. PMID1691735.
Brinkman A, Kortleve DJ, Schuller AG, et al. (1991). "Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability". FEBS Lett. 291 (2): 264–8. doi:10.1016/0014-5793(91)81298-M. PMID1718783. S2CID42755060.
Brewer MT, Stetler GL, Squires CH, et al. (1988). "Cloning, characterization, and expression of a human insulin-like growth factor binding protein". Biochem. Biophys. Res. Commun. 152 (3): 1289–97. doi:10.1016/S0006-291X(88)80425-X. PMID2454104.
Alitalo T, Kontula K, Koistinen R, et al. (1989). "The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism". Hum. Genet. 83 (4): 335–8. doi:10.1007/BF00291377. PMID2478445. S2CID20571796.
Brinkman A, Groffen CA, Kortleve DJ, Drop SL (1989). "Organization of the gene encoding the insulin-like growth factor binding protein IBP-1". Biochem. Biophys. Res. Commun. 157 (3): 898–907. doi:10.1016/S0006-291X(88)80959-8. PMID2849945.