 | |
 | |
| Clinical data | |
|---|---|
| Trade names | Palladia |
| AHFS/Drugs.com | Veterinary Use |
| License data | |
| Routes of administration | By mouth |
| Drug class | Antineoplastic agent |
| ATCvet code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 77% |
| Protein binding | 91%-93% |
| Elimination half-life | 16 h |
| Identifiers | |
| |
| CAS Number |
|
| PubChem CID | |
| ChemSpider | |
| UNII |
|
| KEGG | |
| ChEMBL |
|
| PDB ligand | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C22H25FN4O2 |
| Molar mass | 396.466 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Toceranib is a receptor tyrosine kinase inhibitor and is used in the treatment[1] of canine mast cell tumor also called mastocytoma. Together with masitinib (Kinavet (US)/Masivet (EU/ROW) by AB Science), toceranib is the only dog-specific anti-cancer drug[2] approved by the U.S. Food and Drug Administration (FDA).[3][4] It is sold under the brand name Palladia as its phosphate salt, toceranib phosphate (INN) by Pfizer. It was developed by SUGEN as SU11654,[5] a sister compound to sunitinib, which was later approved for human therapies. Toceranib is likely to act mostly through inhibition of the kit tyrosine kinase, though it may also have an anti-angiogenic effect.
YouTube Encyclopedic
-
1/5Views:6 41152436111 954390
-
Drug Resistance and the Treatment of Cancer
-
Mast Cell Tumor Removal in Dogs - Perioperative Considerations
-
Keynote Presentation: Modernizing Drug Development Through Digital Transformation
-
HCC Whiteboard #2: The Mechanisms of Action of Tyrosine Kinase Inhibitors
-
“One Health” Perspectives From BioPharma
Transcription
References
- ^ London CA, Malpas PB, Wood-Follis SL, et al. (June 2009). "Multi-center, Placebo-controlled, Double-blind, Randomized Study of Oral Toceranib Phosphate (SU11654), a Receptor Tyrosine Kinase Inhibitor, for the Treatment of Dogs with Recurrent (Either Local or Distant) Mast Cell Tumor Following Surgical Excision". Clin Cancer Res. 15 (11): 3856–65. doi:10.1158/1078-0432.CCR-08-1860. PMID 19470739.
- ^ CBS News FDA Approves First-Ever Dog Cancer Drug
- ^ "FDA: First Drug to Treat Cancer in Dogs Approved". U.S. Food and Drug Administration (FDA) (Press release). 3 June 2009. Archived from the original on 22 July 2010. Retrieved 2 October 2021.
- ^ "Palladia New Animal Drug Application" (PDF). U.S. Food and Drug Administration (FDA). 22 May 2009. Archived from the original (PDF) on 16 November 2010. Retrieved 2 October 2021.
- ^ "In Trials for New Cancer Drugs, Family Pets Are Benefiting, Too". The New York Times. 24 November 2006. Retrieved 2 October 2021.
External links
- "Toceranib". Drug Information Portal. U.S. National Library of Medicine.
 | This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it. |
 | This veterinary medicine–related article is a stub. You can help Wikipedia by expanding it. |
This page was last edited on 20 December 2023, at 20:02