Poly(A)-specific ribonuclease

PARN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2A1R, 2A1S, 3CTR
Identifiers
Aliases	PARN, DAN, DKCB6, PFBMFT4, Poly(A)-specific ribonuclease
External IDs	OMIM: 604212 MGI: 1921358 HomoloGene: 31098 GeneCards: PARN
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.12 Start 14,435,700 bp[1] End 14,632,728 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A1 Start 13,355,824 bp[2] End 13,486,034 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus callosum thymus bone marrow cells smooth muscle tissue islet of Langerhans urinary bladder rectum popliteal artery placenta Top expressed in aortic valve ascending aorta renal corpuscle medullary collecting duct Paneth cell saccule ectoderm otic placode primitive streak condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding mRNA 3'-UTR binding protein binding nucleic acid binding nuclease activity exonuclease activity hydrolase activity protein kinase binding cation binding RNA binding poly(A)-specific ribonuclease activity telomerase RNA binding 3'-5'-exoribonuclease activity Cellular component cytoplasm cytosol nucleolus nucleus Biological process mRNA catabolic process female gamete generation regulation of mRNA stability RNA modification nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA poly(A) tail shortening RNA phosphodiester bond hydrolysis, exonucleolytic telomerase RNA stabilization positive regulation of telomere maintenance via telomerase positive regulation of telomerase activity regulation of telomerase RNA localization to Cajal body ncRNA deadenylation box H/ACA RNA 3'-end processing miRNA catabolic process polyadenylation-dependent snoRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5073 74108 Ensembl ENSG00000140694 ENSG00000274829 ENSMUSG00000022685 UniProt O95453 Q8VDG3 RefSeq (mRNA) NM_001134477 NM_001242992 NM_002582 NM_028761 NM_001358452 NM_001358453 RefSeq (protein) NP_001127949 NP_001229921 NP_002573 NP_083037 NP_001345381 NP_001345382 Location (UCSC) Chr 16: 14.44 – 14.63 Mb Chr 16: 13.36 – 13.49 Mb PubMed search [3] [4]
Wikidata
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Poly(A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene.^[5][6]

Function

Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. The amino acid sequence of poly(A)-specific ribonuclease shows homology to the RNase D family of 3'-exonucleases. The protein appears to be localized in both the nucleus and the cytoplasm. It is not stably associated with polysomes or ribosomal subunits.^[6] Hereditary mutations in PARN lead to the bone marrow failure disease dyskeratosis congenita which is caused by defective telomerase RNA processing and degradation in patients.^{[7][8][9][10][11][12][13]}

References

Further reading

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This page was last edited on 9 April 2024, at 19:41