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Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1gene.[5][6]
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RNAse A: The Ribonuclease A enzymatic reaction mechanism
Transcription
Function
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A super-family. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyses 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kochetov AV, Lukasheva VV, Filipenko ML, Mertvetsov NP, Rivkin MI (Sep 1995). "[Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location]". Bioorganicheskaia Khimiia. 21 (9): 691–4. PMID8588814.
Nogués MV, Vilanova M, Cuchillo CM (Nov 1995). "Bovine pancreatic ribonuclease A as a model of an enzyme with multiple substrate binding sites". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1253 (1): 16–24. doi:10.1016/0167-4838(95)00138-k. PMID7492594.
Schienman JE, Holt RA, Auerbach MR, Stewart CB (Aug 2006). "Duplication and divergence of 2 distinct pancreatic ribonuclease genes in leaf-eating African and Asian colobine monkeys". Molecular Biology and Evolution. 23 (8): 1465–79. doi:10.1093/molbev/msl025. PMID16751256.
Sakakibara R, Hashida K, Kitahara T, Ishiguro M (Mar 1992). "Characterization of a unique nonsecretory ribonuclease from urine of pregnant women". Journal of Biochemistry. 111 (3): 325–30. doi:10.1093/oxfordjournals.jbchem.a123757. PMID1587793.
Mizuta K, Awazu S, Yasuda T, Kishi K (Aug 1990). "Purification and characterization of three ribonucleases from human kidney: comparison with urine ribonucleases". Archives of Biochemistry and Biophysics. 281 (1): 144–51. doi:10.1016/0003-9861(90)90424-W. PMID2383019.
Beintema JJ, Wietzes P, Weickmann JL, Glitz DG (Jan 1984). "The amino acid sequence of human pancreatic ribonuclease". Analytical Biochemistry. 136 (1): 48–64. doi:10.1016/0003-2697(84)90306-3. PMID6201087.
Russo N, de Nigris M, Ciardiello A, Di Donato A, D'Alessio G (Aug 1995). "Expression in mammalian cells, purification and characterization of recombinant human pancreatic ribonuclease". FEBS Letters. 369 (2–3): 352. doi:10.1016/0014-5793(95)96890-G. PMID7649283. S2CID45739736.
Seno M, Futami J, Kosaka M, Seno S, Yamada H (Aug 1994). "Nucleotide sequence encoding human pancreatic ribonuclease". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1218 (3): 466–8. doi:10.1016/0167-4781(94)90208-9. PMID8049276.
Pous J, Canals A, Terzyan SS, Guasch A, Benito A, Ribó M, Vilanova M, Coll M (Oct 2000). "Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases". Journal of Molecular Biology. 303 (1): 49–60. doi:10.1006/jmbi.2000.4506. PMID11021969.
Futami J, Maeda T, Kitazoe M, Nukui E, Tada H, Seno M, Kosaka M, Yamada H (Jun 2001). "Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups". Biochemistry. 40 (25): 7518–24. doi:10.1021/bi010248g. PMID11412105.
This page was last edited on 23 December 2023, at 20:35