Protein-coding gene in the species Homo sapiens
Growth differentiation factor 1 (GDF1) is a protein that in humans is encoded by the GDF1 gene .[5]
GDF1 belongs to the transforming growth factor beta superfamily that has a role in left-right patterning and mesoderm induction during embryonic development .[6] [5] [6]
References Further reading
Jiang JC, Kirchman PA, Zagulski M, et al. (1998). "Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human" . Genome Res . 8 (12): 1259–72. doi :10.1101/gr.8.12.1259 PMID 9872981 . Lee SJ (1990). "Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily" . Mol. Endocrinol . 4 (7): 1034–40. doi :10.1210/mend-4-7-1034 PMID 1704486 . Li J, Jia H, Xie L, et al. (2009). "Correlation of inhibitor of differentiation 1 expression to tumor progression, poor differentiation and aggressive behaviors in cervical carcinoma". Gynecol. Oncol . 114 (1): 89–93. doi :10.1016/j.ygyno.2009.03.016 . PMID 19359031 . Ducy P, Karsenty G (2000). "The family of bone morphogenetic proteins" . Kidney Int . 57 (6): 2207–14. doi :10.1046/j.1523-1755.2000.00081.x PMID 10844590 . Lee SJ (1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure" . Proc. Natl. Acad. Sci. U.S.A . 88 (10): 4250–4. Bibcode :1991PNAS...88.4250L . doi :10.1073/pnas.88.10.4250 PMC 51636 PMID 2034669 . Roessler E, Pei W, Ouspenskaia MV, et al. (2009). "Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly" . Mol. Genet. Metab . 98 (1–2): 225–34. doi :10.1016/j.ymgme.2009.05.005 . PMC 2774839 PMID 19553149 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" . Nature . 428 (6982): 529–35. Bibcode :2004Natur.428..529G . doi :10.1038/nature02399 PMID 15057824 . Karkera JD, Lee JS, Roessler E, et al. (2007). "Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans" . Am. J. Hum. Genet . 81 (5): 987–94. doi :10.1086/522890 . PMC 2265655 PMID 17924340 . Polymeropoulos MH, Xiao H, Sikela JM, et al. (1993). "Chromosomal distribution of 320 genes from a brain cDNA library". Nat. Genet . 4 (4): 381–6. doi :10.1038/ng0893-381 . PMID 8401586 . S2CID 33426184 .
Type I
ALK1 (ACVRL1 )
Kinase inhibitors: K-02288ML-347 (LDN-193719, VU0469381) Other inhibitors: Disitertide ALK2 (ACVR1A )
Kinase inhibitors: DMH-1DMH-2
Dorsomorphin (BML-275)
K-02288
ML-347 (LDN-193719, VU0469381) ALK3 (BMPR1A )
Kinase inhibitors: DMH-2Dorsomorphin (BML-275)
K-02288 ALK4 (ACVR1B )
Kinase inhibitors: A 83-01SB-431542 SB-505124 ALK5 (TGFβR1 )ALK6 (BMPR1B )
Agonists: BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )Dibotermin alfa Eptotermin alfa GDF (5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 15 )Radotermin Kinase inhibitors: DMH-2Dorsomorphin (BML-275)
K-02288 ALK7 (ACVR1C )
Kinase inhibitors: A 83-01SB-431542 SB-505124
Type II
TGFβR2
Kinase inhibitors: DMH-2LY-364947 BMPR2 ACVR2A (ACVR2 )
Agonists: Activin (A , B , AB )BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )Dibotermin alfa Eptotermin alfa GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 11 (BMP11) , 15 )Myostatin (GDF8) Nodal Radotermin Decoy receptors: Sotatercept ACVR2B
Agonists: Activin (A , B , AB )BMP (2 , 4 , 6 , 7 )Dibotermin alfa Eptotermin alfa GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) )Myostatin (GDF8) Nodal Osteogenin (BMP3, BMP3A) Radotermin Decoy receptors: Ramatercept AMHR2 (AMHR )
Type III
Unsorted
This page was last edited on 17 April 2022, at 02:20
This page was last edited on 17 April 2022, at 02:20