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PSNCBAM-1

From Wikipedia, the free encyclopedia

PSNCBAM-1
Identifiers
  • 1-(4-chlorophenyl)-3-(3-(6-(pyrrolidin-1-yl)pyridin-2-yl)phenyl)urea
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC22H21ClN4O
Molar mass392.89 g·mol−1
3D model (JSmol)
  • Clc1ccc(NC(=O)Nc2cccc(c2)c3cccc(n3)N4CCCC4)cc1
  • InChI=1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28)
  • Key:HDAYFSFWIPRJSO-UHFFFAOYSA-N

PSNCBAM-1 is a negative allosteric modulator of the cannabinoid CB1 receptor.[1][2]

See also

References

  1. ^ German N, Decker AM, Gilmour BP, Gay EA, Wiley JL, Thomas BF, Zhang Y (September 2014). "Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure–Activity Relationship Studies on 1-(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1)". Journal of Medicinal Chemistry. 57 (18): 7758–7769. doi:10.1021/jm501042u. PMC 4175001. PMID 25162172.
  2. ^ Horswill JG, Bali U, Shaaban S, Keily JF, Jeevaratnam P, Babbs AJ, Reynet C, Wong Kai In P (November 2007). "PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats". British Journal of Pharmacology. 152 (5): 805–814. doi:10.1038/sj.bjp.0707347. PMC 2190018. PMID 17592509.


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This page was last edited on 7 December 2023, at 19:16
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