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CUMYL-THPINACA

From Wikipedia, the free encyclopedia

CUMYL-THPINACA
Legal status
Legal status
Identifiers
  • 1-(oxan-4-ylmethyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC23H27N3O2
Molar mass377.488 g·mol−1
3D model (JSmol)
  • O=C(NC(C)(C)C1=CC=CC=C1)C2=NN(CC3CCOCC3)C4=C2C=CC=C4
  • InChI=1S/C23H27N3O2/c1-23(2,18-8-4-3-5-9-18)24-22(27)21-19-10-6-7-11-20(19)26(25-21)16-17-12-14-28-15-13-17/h3-11,17H,12-16H2,1-2H3,(H,24,27)
  • Key:HINCNLQQLQFMRD-UHFFFAOYSA-N

CUMYL-THPINACA (also known as SGT-42) is an indazole-3-carboxamide based synthetic cannabinoid.[1][2] CUMYL-THPINACA acts as a potent agonist for the cannabinoid receptors, with approximately 6x selectivity for CB1, having an EC50 of 0.1nM for human CB1 receptors and 0.59nM for human CB2 receptors.[3]

Legal status

Sweden's public health agency suggested to classify CUMYL-THPINACA as hazardous substance on November 10, 2014.[4]

As of October 2015 CUMYL-THPINACA is a controlled substance in China.[5]

See also

References

  1. ^ "CUMYL-THPINACA". Cayman Chemical. Retrieved 11 July 2015.
  2. ^ Monti MC, Scheurer E, Mercer-Chalmers-Bender K (July 2021). "Phase I In Vitro Metabolic Profiling of the Synthetic Cannabinoid Receptor Agonists CUMYL-THPINACA and ADAMANTYL-THPINACA". Metabolites. 11 (8): 470. doi:10.3390/metabo11080470. PMC 8398790. PMID 34436411.
  3. ^ WO 2014167530, Bowden MJ, Williamson JP, "Cannabinoid compounds", published 2014-10-16 
  4. ^ "Cannabinoider föreslås bli klassade som hälsofarlig vara". Retrieved 11 July 2015.
  5. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
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This page was last edited on 13 April 2022, at 03:27
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