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APP-FUBINACA is an indazole-based synthetic cannabinoid that has been sold online as a designer drug.[1] Pharmacological testing showed APP-FUBINACA to have only moderate affinity for the CB1 receptor, with a Ki of 708 nM, while its EC50 was not tested.[2] It contains a phenylalanine amino acid residue in its structure.
[3]
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AMB-FUBINACA | Wikipedia audio article
Opiates: drugs, derivatives, and public policy
PAGPAPAKITA, PAGLALARAWAN, AT PAGSALIN NG SUKAT NG ORAS, MINUTO, ARAW, LINGGO BUWAN AT TAON
Csesztregi Tamás: Kábítószerek, designer drogok - a 'sötét oldal' kémiája
PANO MAG DOWNLOAD NG VEDIO EDITOR WITHOUT WATER MARK || Team Narito vlog #08 ||
Transcription
Legality
Sweden's public health agency suggested to classify APP-FUBINACA as hazardous substance on March 24, 2015.[4]
^WO 2009106982, Buchler IP, Hayes MJ, Hedge SG, Hockerman SL, Jones DL, Kortum SW, Rico JG, Tenbrink RE, Wu KK, "Indazole derivatives", published 3 September 2009, assigned to Pfizer Inc
^Cannaert A, Sparkes E, Pike E, Luo JL, Fang A, Kevin RC, et al. (December 2020). "in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA". ACS Chemical Neuroscience. 11 (24): 4434–4446. doi:10.1021/acschemneuro.0c00644. PMID33253529. S2CID227246346.