Cyclic nucleotide gated channel beta 3

CNGB3

Identifiers

CNGB3, ACHM1, Cyclic nucleotide gated channel beta 3, cyclic nucleotide gated channel subunit beta 3

External IDs

OMIM: 605080 MGI: 1353562 HomoloGene: 40908 GeneCards: CNGB3

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8q21.3	Start	86,553,977 bp^[1]
Band	8q21.3	End	86,743,675 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 A3	Start	19,280,850 bp^[2]
Band	4\|4 A3	End	19,510,623 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

retinal pigment epithelium

Achilles tendon

sperm

corpus callosum

bone marrow

canal of the cervix

renal cortex

striated muscle tissue

uterine tube

left uterine tube

Top expressed in

pineal gland

spermatid

myocardium of ventricle

trachea

right ventricle

stria vascularis

neck

testicle

digastric muscle

blastocyst

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	intracellular cGMP-activated cation channel activity voltage-gated potassium channel activity nucleotide binding cGMP binding intracellular cyclic nucleotide activated cation channel activity intracellular cAMP-activated cation channel activity
Cellular component	integral component of membrane photoreceptor outer segment membrane transmembrane transporter complex integral component of plasma membrane
Biological process	regulation of membrane potential cation transport ion transport cation transmembrane transport signal transduction visual perception response to stimulus potassium ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


54714


30952

Ensembl


ENSG00000170289


ENSMUSG00000056494

UniProt


Q9NQW8


Q9JJZ9

RefSeq (mRNA)


NM_019098


NM_013927

RefSeq (protein)


NP_061971


NP_038955

Location (UCSC)

Chr 8: 86.55 – 86.74 Mb

Chr 4: 19.28 – 19.51 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cyclic nucleotide gated channel beta 3, also known as CNGB3, is a human gene encoding an ion channel protein.^[5]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170289 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056494 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CNGB3 cyclic nucleotide gated channel beta 3".

External links

GeneReviews/NIH/NCBI/UW entry on Achromatopsia
OMIM entries on Achromatopsia
CNGB3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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This page was last edited on 30 January 2023, at 00:05

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See also

References

Further reading

External links