KCNK10

KCNK10

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
4BW5, 4XDJ, 4XDK, 4XDL

Identifiers

Aliases

KCNK10, K2p10.1, PPP1R97, TREK-2, TREK2, potassium two pore domain channel subfamily K member 10

External IDs

OMIM: 605873 MGI: 1919508 HomoloGene: 11321 GeneCards: KCNK10

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q31.3	Start	88,180,103 bp^[1]
Band	14q31.3	End	88,326,907 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 E	Start	98,395,696 bp^[2]
Band	12\|12 E	End	98,544,569 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cerebellar vermis

pons

Brodmann area 23

superior vestibular nucleus

ventral tegmental area

jejunal mucosa

parietal lobe

inferior olivary nucleus

middle temporal gyrus

entorhinal cortex

Top expressed in

spermatocyte

ganglionic eminence

medial ganglionic eminence

cerebellar cortex

neural tube

trigeminal ganglion

mesencephalon

duodenum

cerebellar vermis

epithelium of stomach

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	potassium channel activity voltage-gated ion channel activity potassium ion leak channel activity
Cellular component	integral component of membrane plasma membrane membrane integral component of plasma membrane
Biological process	potassium ion transport regulation of ion transmembrane transport memory ion transport signal transduction stabilization of membrane potential potassium ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


54207


72258

Ensembl


ENSG00000100433


ENSMUSG00000033854

UniProt


P57789


n/a

RefSeq (mRNA)


NM_021161 NM_138317 NM_138318


NM_029911 NM_001316664 NM_001316665 NM_001316666

RefSeq (protein)


NP_066984 NP_612190 NP_612191


n/a

Location (UCSC)

Chr 14: 88.18 – 88.33 Mb

Chr 12: 98.4 – 98.54 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium channel, subfamily K, member 10, also known as KCNK10 is a human gene. The protein encoded by this gene, K_2P10.1, is a potassium channel containing two pore-forming P domains.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100433 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033854 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lesage F, Terrenoire C, Romey G, Lazdunski M (September 2000). "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors". The Journal of Biological Chemistry. 275 (37): 28398–405. doi:10.1074/jbc.M002822200. PMID 10880510.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacological Reviews. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP (March 2015). "K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac". Science. 347 (6227): 1256–9. Bibcode:2015Sci...347.1256D. doi:10.1126/science.1261512. PMC 6034649. PMID 25766236.

External links

KCNK10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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This page was last edited on 3 April 2024, at 10:30

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See also

References

Further reading

External links