To install click the Add extension button. That's it.

The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. You could also do it yourself at any point in time.

4,5
Kelly Slayton
Congratulations on this excellent venture… what a great idea!
Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
Live Statistics
English Articles
Improved in 24 Hours
Added in 24 Hours
Languages
Recent
Show all languages
What we do. Every page goes through several hundred of perfecting techniques; in live mode. Quite the same Wikipedia. Just better.
.
Leo
Newton
Brights
Milds

From Wikipedia, the free encyclopedia

CACNA2D2
Identifiers
AliasesCACNA2D2, CACNA2D, calcium voltage-gated channel auxiliary subunit alpha2delta 2, CASVDD
External IDsOMIM: 607082 MGI: 1929813 HomoloGene: 4400 GeneCards: CACNA2D2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005505
NM_001174051
NM_001291101
NM_006030

NM_001174047
NM_001174048
NM_001174049
NM_001174050
NM_020263

RefSeq (protein)

NP_001005505
NP_001167522
NP_001278030
NP_006021

NP_001167518
NP_001167519
NP_001167520
NP_001167521
NP_064659

Location (UCSC)Chr 3: 50.36 – 50.5 MbChr 9: 107.28 – 107.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.[5]

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.[5]

CACNA2D2 containing channels are blocked by amiodarone.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007402 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010066 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2".
  6. ^ "Amiodarone". Drugbank. Retrieved 2019-05-28.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This page was last edited on 3 March 2023, at 22:05
Basis of this page is in Wikipedia. Text is available under the CC BY-SA 3.0 Unported License. Non-text media are available under their specified licenses. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. WIKI 2 is an independent company and has no affiliation with Wikimedia Foundation.