KCNA5

KCNA5

Identifiers

KCNA5, ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1, potassium voltage-gated channel subfamily A member 5

External IDs

OMIM: 176267 MGI: 96662 HomoloGene: 1683 GeneCards: KCNA5

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12p13.32	Start	5,043,879 bp^[1]
Band	12p13.32	End	5,046,788 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6 F3\|6 61.35 cM	Start	126,509,514 bp^[2]
Band	6 F3\|6 61.35 cM	End	126,512,375 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right coronary artery

popliteal artery

ascending aorta

left coronary artery

gastric mucosa

saphenous vein

endothelial cell

vena cava

islet of Langerhans

nucleus accumbens

Top expressed in

olfactory epithelium

trigeminal nerve

retina

endocardial cushion

olfactory tubercle

renal pelvis

nucleus accumbens

myocardium of ventricle

cardiac muscles

arcuate nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	potassium channel inhibitor activity outward rectifier potassium channel activity potassium channel activity scaffold protein binding voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in SA node cell action potential repolarization delayed rectifier potassium channel activity voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization voltage-gated ion channel activity ion channel activity protein binding alpha-actinin binding voltage-gated potassium channel activity signaling receptor binding protein kinase binding
Cellular component	integral component of membrane Golgi apparatus membrane intercalated disc intracellular canaliculus voltage-gated potassium channel complex plasma membrane integral component of plasma membrane potassium channel complex Z disc endoplasmic reticulum perinuclear region of cytoplasm caveola membrane raft cell surface
Biological process	Notch signaling pathway regulation of atrial cardiac muscle cell membrane repolarization positive regulation of myoblast proliferation regulation of potassium ion transport response to hypoxia membrane hyperpolarization regulation of insulin secretion response to hyperoxia regulation of membrane potential regulation of ion transmembrane transport response to mechanical stimulus ion transport response to organic substance membrane repolarization during bundle of His cell action potential positive regulation of G1/S transition of mitotic cell cycle potassium ion transport regulation of vasoconstriction potassium ion homeostasis protein complex oligomerization transmembrane transport potassium ion transmembrane transport negative regulation of potassium ion transport atrial cardiac muscle cell action potential membrane repolarization during SA node cell action potential regulation of heart rate by cardiac conduction protein homooligomerization response to hydrogen peroxide negative regulation of cytosolic calcium ion concentration membrane repolarization during atrial cardiac muscle cell action potential regulation of molecular function transport potassium ion export across plasma membrane
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3741


16493

Ensembl


ENSG00000130037


ENSMUSG00000045534

UniProt


P22460


Q61762

RefSeq (mRNA)


NM_002234


NM_145983

RefSeq (protein)


NP_002225


NP_666095

Location (UCSC)

Chr 12: 5.04 – 5.05 Mb

Chr 6: 126.51 – 126.51 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or K_v1.5, is a protein that in humans is encoded by the KCNA5 gene.^[5]

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Transcription

Function

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12.^[5] Mutations in this gene have been related to both atrial fibrillation^[6] and sudden cardiac death.^[7] KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.

Interactions

KCNA5 has been shown to interact with DLG4,^[8]^[9] PDZ domain-containing proteins such as SAP97,^[10] and Actinin, alpha 2.^[8]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130037 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045534 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: KCNA5 potassium voltage-gated channel, shaker-related subfamily, member 5".
^ Olson TM, Alekseev AE, Liu XK, Park S, Zingman LV, Bienengraeber M, Sattiraju S, Ballew JD, Jahangir A, Terzic A (Jul 2006). "Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation". Human Molecular Genetics. 15 (14): 2185–91. doi:10.1093/hmg/ddl143. PMID 16772329.
^ Nielsen NH, Winkel BG, Kanters JK, Schmitt N, Hofman-Bang J, Jensen HS, Bentzen BH, Sigurd B, Larsen LA, Andersen PS, Haunsø S, Kjeldsen K, Grunnet M, Christiansen M, Olesen SP (Mar 2007). "Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients". Biochemical and Biophysical Research Communications. 354 (3): 776–82. doi:10.1016/j.bbrc.2007.01.048. PMID 17266934.
^ ^a ^b Eldstrom J, Choi WS, Steele DF, Fedida D (Jul 2003). "SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism". FEBS Letters. 547 (1–3): 205–11. doi:10.1016/S0014-5793(03)00668-9. PMID 12860415. S2CID 34857270.
^ Eldstrom J, Doerksen KW, Steele DF, Fedida D (Nov 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS Letters. 531 (3): 529–37. doi:10.1016/S0014-5793(02)03572-X. PMID 12435606. S2CID 40689829.
^ Murata, Mitsunobu; Buckett, Peter D.; Zhou, Jun; Brunner, Michael; Folco, Eduardo; Koren, Gideon (2001-12-01). "SAP97 interacts with Kv1.5 in heterologous expression systems". American Journal of Physiology. Heart and Circulatory Physiology. 281 (6): H2575–H2584. doi:10.1152/ajpheart.2001.281.6.H2575. ISSN 0363-6135. PMID 11709425. S2CID 28915450.
^ Maruoka ND, Steele DF, Au BP, Dan P, Zhang X, Moore ED, Fedida D (May 2000). "alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells". FEBS Letters. 473 (2): 188–94. doi:10.1016/S0014-5793(00)01521-0. PMID 10812072. S2CID 13026110.

External links

Kv1.5+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNA5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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This page was last edited on 27 March 2024, at 21:07

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