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Tampramine

From Wikipedia, the free encyclopedia

Tampramine
Clinical data
Routes of
administration		Oral
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • N,N-Dimethyl-3-(6-phenylpyrido[2,3-b][1,4]benzodiazepin-11-yl)propan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC23H24N4
Molar mass356.473 g·mol−1
3D model (JSmol)
  • CN(C)CCCN1c2ccccc2C(=Nc3c1nccc3)c4ccccc4

Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed.[1][2] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors.[1] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans.[2]

See also

References

  1. ^ a b Kinnier WJ, Tabor RD, Norrell LY (October 1984). "Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake". Biochemical Pharmacology. 33 (19): 3001–5. doi:10.1016/0006-2952(84)90600-2. PMID 6548381.
  2. ^ a b O'Donnell JM, Seiden LS (1985). "Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate". Psychopharmacology. 87 (3): 283–5. doi:10.1007/BF00432708. PMID 3936083. S2CID 20677730.
This page was last edited on 14 April 2022, at 05:33
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