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Xamoterol

From Wikipedia, the free encyclopedia

Xamoterol
Clinical data
ATC code
Identifiers
  • (RS)-N-(2-{[2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino}ethyl)morpholine-4-carboxamide
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H25N3O5
Molar mass339.392 g·mol−1
3D model (JSmol)
  • O=C(NCCNCC(O)COc1ccc(O)cc1)N2CCOCC2
  • InChI=1S/C16H25N3O5/c20-13-1-3-15(4-2-13)24-12-14(21)11-17-5-6-18-16(22)19-7-9-23-10-8-19/h1-4,14,17,20-21H,5-12H2,(H,18,22) checkY
  • Key:DXPOSRCHIDYWHW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Xamoterol is a cardiac stimulant. It works by binding to the β1 adrenergic receptor. It is a 3rd generation adrenergic β receptor partial agonist.[1] It provides cardiac stimulation at rest but it acts as a blocker during exercise.[2]

References

  1. ^ Marlow HF (1989). "Xamoterol, a beta 1-adrenoceptor partial agonist: review of the clinical efficacy in heart failure". British Journal of Clinical Pharmacology. 28 (Suppl 1): 23S–30S. doi:10.1111/j.1365-2125.1989.tb03570.x. PMC 1379873. PMID 2572251.
  2. ^ Rang HP, Dale MM, Ritter JM, Moore PK (1999). Pharmacology (5th ed.). Edinburgh; New York: Churchill Livingstone. p. 163. ISBN 0443059748.
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This page was last edited on 17 September 2023, at 22:07
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