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Lysophosphatidic acid receptor

From Wikipedia, the free encyclopedia

The lysophosphatidic acid receptors (LPARs) are a group of G protein-coupled receptors for lysophosphatidic acid (LPA) that include:

Lysophosphatidic acid receptor 1 (LPAR1; formerly known as EDG2, GPR26)
Lysophosphatidic acid receptor 2 (LPAR2; formerly known as EDG4)
Lysophosphatidic acid receptor 3 (LPAR3; formerly known as EDG7)
Lysophosphatidic acid receptor 4 (LPAR4; formerly known as GPR23, P2RY9)
Lysophosphatidic acid receptor 5 (LPAR5; formerly known as GPR92)
Lysophosphatidic acid receptor 6 (LPAR6; formerly known as GPR87, P2RY5)

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See also

References

Membrane proteins, receptors: cell surface receptors

G protein–coupled receptor

Class A	Eicosanoid receptor (Prostaglandin receptor) Protease-activated receptor Neurotransmitter receptor Purinergic receptor Biogenic amine receptor Olfactory receptor
Class B	Secretin receptor
Class C	Metabotropic glutamate receptor
Class D	Pheromone receptor
Class E	cAMP receptor
Class F	Frizzled/smoothened

Ligand-gated ion channel

Purinergic receptor

Enzyme-linked receptor

Other/ungrouped

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRG (1 2 3 4 5 6 7)
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled & Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

Cell signaling: lipid signaling

Extracellular

Eicosanoids	Classic: Eoxins; Leukotrienes (LTR) Prostacyclin (IPR) Prostaglandins (PGR) Thromboxane (TXR) Nonclassic: EETs Endocannabinoids (CBR) Epi-lipoxins (FPR2) Hepoxilins Isoprostanes Lipoxins (FPR2) Oxoeicosanoids (OXER) Resolvins (FPR2)
Lysophospholipids	LPA (LPAR) S1P (S1PR)
Steroids	Bile acids (GPBAR) Neurosteroids Pheromones (VNR)
Others	PAF (PAFR) Retinal (RHO)

Intracellular

Nuclear receptor	Steroids: Sex steroids: Androgens (AR) Estrogens (ER) Progestogens (PR); Corticosteroids: Glucocorticoids (GR) Mineralocorticoids (MR); Others: Bile acids (FXR) Calcitriol (VDR); Others: Eicosanoids (PPAR) Free fatty acids (PPAR) Retinoic acid (RAR, RXR)
Second messenger	General: Arachidonic acid DAG (PKC, TRPC) IP₃ (IP₃R, RyR) Phosphatidic acid Phosphoinositides: PIP₂ (IRKs) PIP₃ (PKB/Akt, Btk, PDPK1) PtdIns(3,4)P₂ (PKB/Akt, PDPK1); Sphingolipids: C1P Ceramide (CAPPs, KSR1, PKCζ, CTSD) Glucosylceramides S1P Sphingosine (SDK1, PKH, YPK)

Precursors

General	Fatty acids (ω-3, ω-6)
Steroids	Squalene Lanosterol Cholesterol

Lysophospholipid signaling modulators

Receptor
(ligands)

Agonists: 1-Oleoyl-LPA
1-Palmitoyl-LPA
GRI-977143
LPA
OMPT

Antagonists: H2L-5186303
H2L-5765834
Ki-16425
TC-LPA5 4
VPC-32183

Agonists: Amiselimod
Cenerimod
Ceralifimod
CS-2100
CYM-5442
CYM-5520
CYM 5541
CYM-50260
CYM-50308
Dihydro-S1P (sphinganine 1-phosphate)
Fingolimod
Fingolimod phosphate
KRP-203
Mocravimod
Ozanimod
Phyto-S1P
Ponesimod
RP-001
RP-002
RPC-1063
SEW-2871
Siponimod
S1P
SPC
TC-G 1006
TC-SP 14
W-061
XAX-162

Antagonists: CS-0777
CYM-50358
JTE-013
TY-52156
VPC-23019
W-146

Unsorted: Etrasimod

Enzyme
(inhibitors)

SPTTooltip Serine C-palmitoyltransferase	Myriocin
Ceramidase	Ceranib 1 OEA
SphKTooltip Sphingosine kinase	N,N-DMS Safingol SKI II

Others

Precursors: LPA: LPC; S1P: Palmitoyl-CoA
Serine
3-Ketosphinganine (dehydrosphingosine)
Dihydrosphingosine (sphinganine)
Dihydroceramide
Ceramide
Sphingosine

See also: Receptor/signaling modulators

This biochemistry article is a stub. You can help Wikipedia by expanding it.

This page was last edited on 24 September 2018, at 18:01

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