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When this gene was first cloned, it was proposed to encode an adrenomedullin receptor.[6] However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).[7]
It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.[8]
^Hänze J, Dittrich K, Dötsch J, Rascher W (November 1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–188. doi:10.1006/bbrc.1997.7631. PMID9367907.
^Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ (March 1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–837. doi:10.1006/bbrc.1998.8349. PMID9535752.
^McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–339. Bibcode:1998Natur.393..333M. doi:10.1038/30666. PMID9620797. S2CID4364526.
Further reading
Lah JJ, Frishman WH (2002). "Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential". Heart Disease (Hagerstown, Md.). 2 (3): 259–65. PMID11728267.
Fowler DE, Wang P (2002). "The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review)". Int. J. Mol. Med. 9 (5): 443–9. doi:10.3892/ijmm.9.5.443. PMID11956648.
Kato J, Kitamura K, Kangawa K, Eto T (1995). "Receptors for adrenomedullin in human vascular endothelial cells". Eur. J. Pharmacol. 289 (2): 383–385. doi:10.1016/0922-4106(95)90117-5. PMID7621913.
Hänze J, Dittrich K, Dötsch J, Rascher W (1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–188. doi:10.1006/bbrc.1997.7631. PMID9367907.
Kennedy SP, Sun D, Oleynek JJ, et al. (1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–837. doi:10.1006/bbrc.1998.8349. PMID9535752.
Forneris M, Gottardo L, Albertin G, et al. (2002). "Expression and function of adrenomedullin and its receptors in Conn's adenoma cells". Int. J. Mol. Med. 8 (6): 675–9. doi:10.3892/ijmm.8.6.675. PMID11712085.
Hänze J, Groneberg DA, Rose F, et al. (2002). "Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia". Biochem. Biophys. Res. Commun. 291 (5): 1160–1165. doi:10.1006/bbrc.2002.6595. PMID11883938.
Chosa E, Hamada H, Kitamura K, et al. (2003). "Expression of adrenomedullin and its receptor by chondrocyte phenotype cells". Biochem. Biophys. Res. Commun. 303 (1): 379–386. doi:10.1016/S0006-291X(03)00347-4. PMID12646214.
Xu P, Dai AG, Zhou HD, et al. (2004). "[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease]". Zhonghua Jie He He Hu Xi Za Zhi. 26 (12): 765–8. PMID14720432.
This page was last edited on 2 January 2024, at 20:44