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The TRHR is found on the cell membrane of thyrotropes of the anterior pituitary. When the TRHR is activated it associates with a Gαq/11 protein. The TRHR-G protein complex then activates phospholipase C, which causes the formation of inositol triphosphate (IP3) and diacylglycerol (DAG). This leads to an increase in cytoplasmic calcium ion concentrations which stimulates the exocytosis of thyroid-stimulating hormone (TSH) into the blood.
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Thyroid Gland: Hypothalamic-Pituitary-Thyroid Axis - Role of Thyrotropin Releasing Hormone (TRH)
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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This page was last edited on 10 March 2024, at 00:33