Type of drug
Not to be confused with Selective androgen receptor modulator.
A selective androgen receptor degrader or downregulator (SARD) is a type of drug which interacts with the androgen receptor (AR) such that it causes the AR to be degraded and thus downregulated.[1] They are under investigation for the treatment of prostate cancer and other androgen-dependent conditions.[1]
As of 2017, dimethylcurcumin (ASC-J9), a SARD, is under development for the treatment of acne vulgaris.[2]
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The Estrogen Receptor (II): Molecular & Cellular Mechanisms
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See also
References
- ^ a b Lai, AC; Crews, CM (25 November 2016). "Induced protein degradation: an emerging drug discovery paradigm". Nature Reviews. Drug Discovery. 16 (2): 101–114. doi:10.1038/nrd.2016.211. PMC 5684876. PMID 27885283.
- ^ "ASCJ 9 - AdisInsight".
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This page was last edited on 30 November 2021, at 17:13