Mucin 17

MUC17

Identifiers

MUC17, MUC3, MUC-17, MUC-3, mucin 17, cell surface associated

External IDs

OMIM: 608424 HomoloGene: 134646 GeneCards: MUC17

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q22.1	Start	101,020,072 bp^[1]
Band	7q22.1	End	101,058,859 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

duodenum

rectum

transverse colon

right lobe of liver

smooth muscle tissue

appendix

sural nerve

islet of Langerhans

right lung

prostate

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	PDZ domain binding extracellular matrix constituent, lubricant activity protein binding
Cellular component	Golgi lumen integral component of membrane extracellular region membrane external side of plasma membrane apical plasma membrane plasma membrane collagen-containing extracellular matrix
Biological process	cellular homeostasis O-glycan processing stimulatory C-type lectin receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


140453


n/a

Ensembl


ENSG00000169876


n/a

UniProt


Q685J3


n/a

RefSeq (mRNA)


NM_001004430 NM_001040105


n/a

RefSeq (protein)


NP_001035194


n/a

Location (UCSC)

Chr 7: 101.02 – 101.06 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Mucin-17 is a protein that in humans is encoded by the MUC17 gene.^[3]^[4]

Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.[supplied by OMIM]^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169876 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gum JR Jr; Crawley SC; Hicks JW; Szymkowski DE; Kim YS (Feb 2002). "MUC17, a novel membrane-tethered mucin". Biochem Biophys Res Commun. 291 (3): 466–475. doi:10.1006/bbrc.2002.6475. PMID 11855812.
^ ^a ^b "Entrez Gene: MUC17 mucin 17, cell surface associated".

Kitamoto S, Yamada N, Yokoyama S, et al. (2011). "DNA methylation and histone H3-K9 modifications contribute to MUC17 expression". Glycobiology. 21 (2): 247–56. doi:10.1093/glycob/cwq155. PMC 3010767. PMID 20926598.
Malmberg EK, Pelaseyed T, Petersson AC, et al. (2008). "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine" (PDF). Biochem. J. 410 (2): 283–9. doi:10.1042/BJ20071068. PMID 17990980. S2CID 207870.
Moniaux N, Junker WM, Singh AP, et al. (2006). "Characterization of human mucin MUC17. Complete coding sequence and organization". J. Biol. Chem. 281 (33): 23676–23685. doi:10.1074/jbc.M600302200. PMID 16737958.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Ho JJ, Jaituni RS, Crawley SC, et al. (2004). "N-glycosylation is required for the surface localization of MUC17 mucin". Int. J. Oncol. 23 (3): 585–92. doi:10.3892/ijo.23.3.585. PMID 12888891.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wang R, Khatri IA, Forstner JF (2002). "C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components". Biochem. J. 366 (Pt 2): 623–31. doi:10.1042/BJ20020289. PMC 1222797. PMID 12027806.
Van Klinken BJ, Van Dijken TC, Oussoren E, et al. (1997). "Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region". Biochem. Biophys. Res. Commun. 238 (1): 143–148. doi:10.1006/bbrc.1997.7258. PMID 9299468.

Protein, glycoconjugate: glycoproteins and glycopeptides

Mucoproteins

Mucin	CD43 CD164 MUC1 MUC2 MUC3A MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUC8 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC20
Other	Haptoglobin Intrinsic factor Orosomucoid Peptidoglycan Phytohaemagglutinin Ovomucin

Proteoglycans

CS/DS	Decorin Biglycan Versican
HS/CS	Testican Perlecan
CS	Chondroitin sulfate proteoglycans: Aggrecan Neurocan Brevican CD44 CSPG4 CSPG5 Platelet factor 4 Structural maintenance of chromosomes 3
KS	Fibromodulin Lumican Keratocan
HS	Syndecan 1

Other

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This page was last edited on 3 March 2023, at 23:54

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References

Further reading