Cathepsin O

CTSO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ATK, 1AU0, 1AU2, 1AU3, 1AU4, 1AYU, 1AYV, 1AYW, 1BGO, 1BY8, 1MEM, 1NL6, 1NLJ, 1Q6K, 1SNK, 1TU6, 1U9V, 1U9W, 1U9X, 1VSN, 1YK7, 1YK8, 1YT7, 2ATO, 2AUX, 2AUZ, 2BDL, 2R6N, 3C9E, 3H7D, 3KW9, 3KWB, 3KWZ, 3KX1, 3O0U, 3O1G, 3OVZ, 4DMX, 4DMY, 7PCK, 4LEG, 4N79, 4N8W
Identifiers
Aliases	CTSO, CTSO1, cathepsin O
External IDs	OMIM: 600550; MGI: 2139628; HomoloGene: 1020; GeneCards: CTSO; OMA:CTSO - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q32.1 Start 155,921,580 bp[1] End 155,953,912 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E3 Start 81,839,908 bp[2] End 81,864,032 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gallbladder endometrium right coronary artery smooth muscle tissue placenta gastric mucosa liver duodenum monocyte Top expressed in otolith organ utricle median eminence carotid body left lobe of liver white adipose tissue suprachiasmatic nucleus islet of Langerhans sciatic nerve substantia nigra More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity cysteine-type endopeptidase activity cysteine-type peptidase activity hydrolase activity Cellular component lysosome extracellular space Biological process proteolysis involved in cellular protein catabolic process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1519 229445 Ensembl ENSG00000256043 ENSMUSG00000028015 UniProt P43234 Q8BM88 RefSeq (mRNA) NM_001334 NM_177662 RefSeq (protein) NP_001325 NP_808330 Location (UCSC) Chr 4: 155.92 – 155.95 Mb Chr 3: 81.84 – 81.86 Mb PubMed search [3] [4]
Wikidata
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Cathepsin O is an enzyme encoded by the CTSO gene in humans.^[5][6]

Function

Cathepsin O is a cysteine cathepsin, a cysteine protease and a member of the cathepsin family. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases, and its proteolytic activity was abolished by an inhibitor of cysteine proteinase.^[6]

References

Further reading

External links

• The MEROPS online database for peptidases and their inhibitors: C01.035

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

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This page was last edited on 6 May 2024, at 05:39