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Caspase 14 is an enzyme that in humans is encoded by the CASP14gene.[5][6][7]
The CASP14 gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligandin vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.[7]
^Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Åsa; Kampf, Caroline; Sjöstedt, Evelina (2015-01-23). "Tissue-based map of the human proteome". Science. 347 (6220): 1260419. doi:10.1126/science.1260419. ISSN0036-8075. PMID25613900. S2CID802377.
^Thul, Peter J.; Åkesson, Lovisa; Wiking, Mikaela; Mahdessian, Diana; Geladaki, Aikaterini; Blal, Hammou Ait; Alm, Tove; Asplund, Anna; Björk, Lars (2017-05-26). "A subcellular map of the human proteome". Science. 356 (6340): eaal3321. doi:10.1126/science.aal3321. ISSN0036-8075. PMID28495876. S2CID10744558.
Further reading
Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID1286667. S2CID41855774.
Ahmad M, Srinivasula SM, Hegde R, et al. (1998). "Identification and characterization of murine caspase-14, a new member of the caspase family". Cancer Res. 58 (22): 5201–5. PMID9823333.
Eckhart L, Ban J, Fischer H, Tschachler E (2000). "Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation". Biochem. Biophys. Res. Commun. 277 (3): 655–9. doi:10.1006/bbrc.2000.3698. PMID11062009.
Pistritto G, Jost M, Srinivasula SM, et al. (2003). "Expression and transcriptional regulation of caspase-14 in simple and complex epithelia". Cell Death Differ. 9 (9): 995–1006. doi:10.1038/sj.cdd.4401061. PMID12181750. S2CID23933663.
Chien AJ, Presland RB, Kuechle MK (2002). "Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation". Biochem. Biophys. Res. Commun. 296 (4): 911–7. doi:10.1016/S0006-291X(02)02015-6. PMID12200134.
Park K, Kuechle MK, Choe Y, et al. (2006). "Expression and characterization of constitutively active human caspase-14". Biochem. Biophys. Res. Commun. 347 (4): 941–8. doi:10.1016/j.bbrc.2006.06.156. PMID16854378.
Hsu S, Qin H, Dickinson D, et al. (2007). "Expression of caspase-14 reduces tumorigenicity of skin cancer cells". In Vivo. 21 (2): 279–83. PMID17436577.
This page was last edited on 10 March 2024, at 02:35