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From Wikipedia, the free encyclopedia

Cathepsin W is a protein that in humans is encoded by the CTSW gene.[5][6][7]

The protein encoded by this gene, a member of the peptidase C1 family of cysteine cathepsins, is a cysteine protease cathepsin that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the cell membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.[7]

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References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172543 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024910 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Linnevers C, Smeekens SP, Brömme D (May 1997). "Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes". FEBS Lett. 405 (3): 253–9. doi:10.1016/S0014-5793(97)00118-X. PMID 9108299. S2CID 45420314.
  6. ^ Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D (Aug 1998). "Genomic structure, chromosomal localization, and expression of human cathepsin W". Biochem Biophys Res Commun. 248 (2): 255–61. doi:10.1006/bbrc.1998.8954. PMID 9675123.
  7. ^ a b "Entrez Gene: CTSW cathepsin W".

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This page was last edited on 8 March 2024, at 07:49
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