CEP70

CEP70

Identifiers

CEP70, BITE, centrosomal protein 70

External IDs

OMIM: 614310 MGI: 1915371 HomoloGene: 11387 GeneCards: CEP70

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q22.3	Start	138,494,344 bp^[1]
Band	3q22.3	End	138,594,538 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 E3.3	Start	99,243,367 bp^[2]
Band	9\|9 E3.3	End	99,300,404 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

sperm

right uterine tube

ganglionic eminence

body of pancreas

duodenum

jejunal mucosa

right lobe of thyroid gland

left lobe of thyroid gland

secondary oocyte

Top expressed in

secondary oocyte

spermatocyte

trigeminal ganglion

substantia nigra

saccule

ganglionic eminence

spermatid

otic placode

neural tube

seminiferous tubule

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding identical protein binding gamma-tubulin binding
Cellular component	microtubule organizing center cytoskeleton cytoplasm nucleoplasm cytosol nuclear membrane centrosome
Biological process	G2/M transition of mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle cilium assembly regulation of microtubule cytoskeleton organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


80321


68121

Ensembl


ENSG00000114107


ENSMUSG00000056267

UniProt


Q8NHQ1


Q6IQY5

RefSeq (mRNA)

NM_001288964 NM_001288965 NM_001288966 NM_001288967 NM_024491
NM_001320598 NM_001320599 NM_001320600


NM_023873

RefSeq (protein)

NP_001275893 NP_001275894 NP_001275895 NP_001275896 NP_001307527
NP_001307528 NP_001307529 NP_077817


NP_076362

Location (UCSC)

Chr 3: 138.49 – 138.59 Mb

Chr 9: 99.24 – 99.3 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene.^[5]^[6] The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.^[7]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114107 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056267 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
^ "Entrez Gene: CEP70 centrosomal protein 70kDa".
^ Shi X, Sun X, Liu M, Li D, Aneja R, Zhou J (September 2011). "CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly". J. Biol. Chem. 286 (38): 33401–8. doi:10.1074/jbc.M111.252262. PMC 3190865. PMID 21795687.

External links

Human CEP70 genome location and CEP70 gene details page in the UCSC Genome Browser.

Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 Lck PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 3 March 2023, at 22:06

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References

External links

Further reading