CEP152

CEP152

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4N7V

Identifiers

Aliases

CEP152, MCPH4, MCPH9, SCKL5, centrosomal protein 152

External IDs

OMIM: 613529 MGI: 2139083 HomoloGene: 37159 GeneCards: CEP152

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q21.1	Start	48,712,928 bp^[1]
Band	15q21.1	End	48,811,146 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 F1	Start	125,405,008 bp^[2]
Band	2\|2 F1	End	125,467,033 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

sperm

sural nerve

Achilles tendon

bone marrow

spongy bone

bone marrow cells

monocyte

ganglionic eminence

placenta

Top expressed in

saccule

Paneth cell

medullary collecting duct

otic placode

secondary oocyte

Jacobson's organ

renal corpuscle

pharynx

primitive streak

bone marrow

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein kinase binding protein binding
Cellular component	deuterosome cytosol centriole nucleoplasm cytoplasm pericentriolar material microtubule organizing center cytoskeleton centrosome
Biological process	cell projection organization G2/M transition of mitotic cell cycle de novo centriole assembly involved in multi-ciliated epithelial cell differentiation centrosome duplication centriole replication ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


22995


99100

Ensembl


ENSG00000103995


ENSMUSG00000068394

UniProt


O94986


A2AUM9

RefSeq (mRNA)


NM_001194998 NM_014985


NM_001081091

RefSeq (protein)


NP_001181927 NP_055800


NP_001074560

Location (UCSC)

Chr 15: 48.71 – 48.81 Mb

Chr 2: 125.41 – 125.47 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene.^[5] It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.^[6]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103995 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068394 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: centrosomal protein 152kDa".
^ Blachon S, Gopalakrishnan J, Omori Y, Polyanovsky A, Church A, Nicastro D, Malicki J, Avidor-Reiss T (December 2008). "Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication". Genetics. 180 (4): 2081–94. doi:10.1534/genetics.108.095141. PMC 2600943. PMID 18854586.

External links

Human CEP152 genome location and CEP152 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: O94986 (Centrosomal protein of 152 kDa) at the PDBe-KB.

Nakayama M, Kikuno R, Ohara O (2002). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Nagase T, Ishikawa K, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". J. Cell Biol. 129 (6): 1617–28. doi:10.1083/jcb.129.6.1617. PMC 2291169. PMID 7790358.
Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell. 5 (1): 113–25. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mayor T, Stierhof YD, Tanaka K, et al. (2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837–46. doi:10.1083/jcb.151.4.837. PMC 2169446. PMID 11076968.
Petretti C, Savoian M, Montembault E, et al. (2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation". EMBO Rep. 7 (4): 418–24. doi:10.1038/sj.embor.7400639. PMC 1456919. PMID 16462731.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Takahashi M, Yamagiwa A, Nishimura T, et al. (2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.

v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 Lck PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 4 March 2023, at 01:57

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