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Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350gene.[5][6][7]
CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.[8]
It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.[7]
Makalowska I, Sood R, Faruque MU, et al. (2002). "Identification of six novel genes by experimental validation of GeneMachine predicted genes". Gene. 284 (1–2): 203–13. doi:10.1016/S0378-1119(01)00897-6. PMID11891061.
This page was last edited on 11 October 2022, at 13:53