CEP55

CEP55

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3E1R, 3WUT, 3WUU, 3WUV

Identifiers

Aliases

CEP55, C10orf3, CT111, URCC6, centrosomal protein 55, MARCH

External IDs

OMIM: 610000 MGI: 1921357 HomoloGene: 10019 GeneCards: CEP55

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q23.33	Start	93,496,612 bp^[1]
Band	10q23.33	End	93,529,092 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 C2	Start	38,043,459 bp^[2]
Band	19\|19 C2	End	38,062,871 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

sperm

ganglionic eminence

stromal cell of endometrium

rectum

testicle

appendix

amniotic fluid

lymph node

bone marrow

Top expressed in

secondary oocyte

spermatocyte

cumulus cell

atrioventricular valve

medial ganglionic eminence

abdominal wall

spermatid

atrium

superior cervical ganglion

Paneth cell

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding
Cellular component	cytoplasm centriole centrosome cleavage furrow cytoskeleton membrane intercellular bridge midbody microtubule organizing center plasma membrane Flemming body
Biological process	cell division cell cycle septum digestion after cytokinesis mitotic cytokinesis mitotic metaphase plate congression nucleus organization establishment of protein localization renal system development cranial skeletal system development multicellular organism development regulation of phosphatidylinositol 3-kinase signaling midbody abscission
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


55165


74107

Ensembl


ENSG00000138180


ENSMUSG00000024989

UniProt


Q53EZ4


Q8BT07

RefSeq (mRNA)


NM_001127182 NM_018131


NM_001164362 NM_028293 NM_028760 NM_001360663

RefSeq (protein)


NP_001120654 NP_060601


NP_001157834 NP_082569 NP_083036 NP_001347592

Location (UCSC)

Chr 10: 93.5 – 93.53 Mb

Chr 19: 38.04 – 38.06 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Centrosomal protein of 55 kDa (Cep55), is a protein that in humans is encoded by the CEP55 gene.^[5]^[6]

Cep55 is a mitotic phosphoprotein that plays a key role in cytokinesis, the final stage of cell division.^[7] and cilia formation in neural stem cells.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138180 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024989 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fabbro M, Zhou BB, Takahashi M, Sarcevic B, Lal P, Graham ME, Gabrielli BG, Robinson PJ, Nigg EA, Ono Y, Khanna KK (Oct 2005). "Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis". Dev Cell. 9 (4): 477–88. doi:10.1016/j.devcel.2005.09.003. PMID 16198290.
^ "Entrez Gene: CEP55 centrosomal protein 55kDa".
^ van der Horst A, Simmons J, Khanna KK (November 2009). "Cep55 stabilization is required for normal execution of cytokinesis". Cell Cycle. 8 (22): 3742–3749. doi:10.4161/cc.8.22.10047. PMID 19855176.
^ Behnam Rashidieh; Belal Shohayeb; Amanda Louise Bain; Patrick R. J. Fortuna; Debottam Sinha; Andrew Burgess; Richard Mills; Rachael C. Adams; J. Alejandro Lopez; Peter Blumbergs; John Finnie; Murugan Kalimutho; Michael Piper; James Edward Hudson; Dominic C. H. Ng; Kum Kum Khanna (October 2021). "Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis". PLOS Genetics. 17 (10): e1009334. doi:10.1371/journal.pgen.1009334. PMC 8577787. PMID 34710087.

External links

Human CEP55 genome location and CEP55 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Martinez-Garay I, Rustom A, Gerdes HH, Kutsche K (2006). "The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody". Genomics. 87 (2): 243–53. doi:10.1016/j.ygeno.2005.11.006. PMID 16406728.
Zhao WM, Seki A, Fang G (2006). "Cep55, a Microtubule-bundling Protein, Associates with Centralspindlin to Control the Midbody Integrity and Cell Abscission during Cytokinesis". Mol. Biol. Cell. 17 (9): 3881–96. doi:10.1091/mbc.E06-01-0015. PMC 1593165. PMID 16790497.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Chen CH, Lu PJ, Chen YC, et al. (2007). "FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway". Oncogene. 26 (29): 4272–83. doi:10.1038/sj.onc.1210207. PMID 17237822.
Carlton JG, Martin-Serrano J (2007). "Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery". Science. 316 (5833): 1908–12. Bibcode:2007Sci...316.1908C. doi:10.1126/science.1143422. PMID 17556548. S2CID 29191843.
Morita E, Sandrin V, Chung HY, et al. (2007). "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis". EMBO J. 26 (19): 4215–27. doi:10.1038/sj.emboj.7601850. PMC 2230844. PMID 17853893.

v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 Lck PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

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This page was last edited on 9 November 2023, at 01:18

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References

External links

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