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From Wikipedia, the free encyclopedia

SLC20A1
Identifiers
AliasesSLC20A1, GLVR1, Glvr-1, PIT1, PiT-1, solute carrier family 20 member 1
External IDsOMIM: 137570 MGI: 108392 HomoloGene: 38049 GeneCards: SLC20A1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005415

NM_001159593
NM_015747
NM_001355252

RefSeq (protein)

NP_005406

NP_001153065
NP_056562
NP_001342181

Location (UCSC)Chr 2: 112.65 – 112.66 MbChr 2: 129.04 – 129.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium-dependent phosphate transporter 1 is a protein that in humans is encoded by the SLC20A1 gene.[5][6]

Retrovirus receptors allow infection of human and murine cells by various retroviruses. The receptors that have been identified at the molecular level include CD4 (MIM 186940) for human immunodeficiency virus, Rec1 for murine ecotropic virus, and GLVR1 for gibbon ape leukemia virus (see MIM 182090). These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a sodium-dependent phosphate symporter.[supplied by OMIM][6]

Research

It was reported that mutations of the gene may cause epispadias or bladder exstrophy.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144136 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027397 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kavanaugh MP, Miller DG, Zhang W, Law W, Kozak SL, Kabat D, Miller AD (Aug 1994). "Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters". Proc Natl Acad Sci U S A. 91 (15): 7071–5. Bibcode:1994PNAS...91.7071K. doi:10.1073/pnas.91.15.7071. PMC 44340. PMID 8041748.
  6. ^ a b "Entrez Gene: SLC20A1 solute carrier family 20 (phosphate transporter), member 1".
  7. ^ Rieke JM, Zhang R, Braun D, Yilmaz Ö, Japp AS, Lopes FM, et al. (2020). "SLC20A1 Is Involved in Urinary Tract and Urorectal Development". Frontiers in Cell and Developmental Biology. 8: 567. doi:10.3389/fcell.2020.00567. PMC 7426641. PMID 32850778.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This page was last edited on 3 March 2023, at 21:30
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