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From Wikipedia, the free encyclopedia

SLC41A1
Identifiers
AliasesSLC41A1, MgtE, solute carrier family 41 member 1, NPHPL2
External IDsOMIM: 610801 MGI: 2444823 HomoloGene: 14871 GeneCards: SLC41A1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173854

NM_173865

RefSeq (protein)

NP_776253

NP_776290

Location (UCSC)Chr 1: 205.79 – 205.81 MbChr 1: 131.76 – 131.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SLC41A1 is a protein that in humans is encoded by the gene SLC41A1.[5] It is homologous to the prokaryotic Mg++ transfer protein MgtE[6]

Mutations in this gene have been associated to Nephronophthisis-like phenotypes.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133065 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013275 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wabakken T, Rian E, Kveine M, Aasheim HC (July 2003). "The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters". Biochemical and Biophysical Research Communications. 306 (3): 718–24. doi:10.1016/S0006-291X(03)01030-1. PMID 12810078.
  6. ^ Goytain A, Quamme GA (May 2005). "Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters". Physiological Genomics. 21 (3): 337–42. doi:10.1152/physiolgenomics.00261.2004. PMID 15713785.
  7. ^ Hurd TW, Otto EA, Mishima E, Gee HY, Inoue H, Inazu M, et al. (May 2013). "Mutation of the Mg2+ transporter SLC41A1 results in a nephronophthisis-like phenotype". Journal of the American Society of Nephrology. 24 (6): 967–77. doi:10.1681/ASN.2012101034. PMC 3665398. PMID 23661805.
This page was last edited on 3 March 2023, at 19:54
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