SLC22A13

SLC22A13

Identifiers

SLC22A13, OAT10, OCTL1, OCTL3, ORCTL-3, ORCTL3, solute carrier family 22 member 13

External IDs

OMIM: 604047 MGI: 2143107 HomoloGene: 3140 GeneCards: SLC22A13

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p22.2	Start	38,265,812 bp^[1]
Band	3p22.2	End	38,278,757 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 F3	Start	119,022,040 bp^[2]
Band	9\|9 F3	End	119,038,164 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

kidney

renal cortex

stromal cell of endometrium

metanephros

blood

cerebellum

cerebellar cortex

gastrocnemius muscle

cerebellar hemisphere

prefrontal cortex

Top expressed in

kidney

proximal tubule

proximal straight tubule

morula

thyroid gland

proximal convoluted tubule

Greater petrosal nerve

right ventricle

ascending aorta

jejunum

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transmembrane transporter activity organic cation transmembrane transporter activity nicotinate transmembrane transporter activity inorganic anion exchanger activity sodium-independent organic anion transmembrane transporter activity
Cellular component	integral component of plasma membrane apical plasma membrane membrane extracellular exosome integral component of membrane plasma membrane
Biological process	nicotinate transport transmembrane transport urate transport organic cation transport NAD biosynthesis via nicotinamide riboside salvage pathway inorganic anion transport sodium-independent organic anion transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9390


102570

Ensembl


ENSG00000172940


ENSMUSG00000074028

UniProt


Q9Y226


Q6A4L0

RefSeq (mRNA)


NM_004256


NM_133980

RefSeq (protein)


NP_004247


NP_598741

Location (UCSC)

Chr 3: 38.27 – 38.28 Mb

Chr 9: 119.02 – 119.04 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene. ^[5]

Function

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172940 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074028 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Solute carrier family 22 member 13". Retrieved 2017-10-05.

Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W, Burckhardt BC, Sabolic I, Burckhardt G (2008). "Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)". J. Biol. Chem. 283 (24): 16332–41. doi:10.1074/jbc.M800737200. PMID 18411268.
Irshad S, Mahul-Mellier AL, Kassouf N, Lemarie A, Grimm S (2009). "Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers". Cell Death Differ. 16 (6): 890–8. doi:10.1038/cdd.2009.21. PMC 2683172. PMID 19282870.
Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, Sabolić I, Koepsell H, Brockmöller J (2009). "The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin". Clin. Pharmacol. Ther. 86 (3): 299–306. doi:10.1038/clpt.2009.92. PMID 19536068. S2CID 8583867.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Schulz C, Fork C, Bauer T, Golz S, Geerts A, Schömig E, Gründemann D (2014). "SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct". Biochem. J. 457 (2): 243–51. doi:10.1042/BJ20130654. PMID 24147638.
AbuAli G, Chaisaklert W, Stelloo E, Pazarentzos E, Hwang MS, Qize D, Harding SV, Al-Rubaish A, Alzahrani AJ, Al-Ali A, Sanders TA, Aboagye EO, Grimm S (2015). "The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis". Oncogene. 34 (13): 1718–28. doi:10.1038/onc.2014.93. PMC 4119473. PMID 24769897.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 27 March 2022, at 07:34

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Function

References

Further reading