Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin.[1] There are two different subtypes CCKA and CCKB which are ~50% homologous:[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.
| Protein | Gene | Tissue distribution | Preferred ligand | Function | Mechanism |
|---|---|---|---|---|---|
| CCKA (CCK1) | CCKAR | primarily gastrointestinal tract, lesser amounts in the CNS | sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK | stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility | Gq[3][4] |
| CCKB (CCK2) | CCKBR | primarily CNS, lesser amounts in the gastrointestinal tract | gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides) | regulation of nociception, anxiety, memory and hunger | Gq/G11[4] |
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Cholecystokinin (CCK) - Release, Function, and Regulation
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Control of the GI Tract: The roles of Gastrin, CCK, Secretin, Motilin and Gastric Inhibitory Peptide
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Control of the GI tract | Gastrointestinal system physiology | NCLEX-RN | Khan Academy
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Secretin || Production,discovery and mode of action
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TRACO 2017 - Clinical trials and Precision Medicine
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References
- ^ Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP (December 1999). "International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors". Pharmacological Reviews. 51 (4): 745–781. PMID 10581329.
- ^ Dufresne M, Seva C, Fourmy D (July 2006). "Cholecystokinin and gastrin receptors". Physiological Reviews. 86 (3): 805–847. doi:10.1152/physrev.00014.2005. PMID 16816139.
- ^ Wank SA (April 1998). "G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family". The American Journal of Physiology. 274 (4 Pt 1): G607–G613. doi:10.1152/ajpgi.1998.274.4.g607. PMID 9575840. S2CID 27674659.
- ^ a b Beinfeld M, Chen Q, Gao F, Liddle RA, Miller LJ, Rehfeld J (2019-09-16). "Cholecystokinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database". IUPHAR/BPS Guide to Pharmacology CITE. 2019 (4). doi:10.2218/gtopdb/F15/2019.4. S2CID 203825385.
External links
- Cholecystokinin+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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This page was last edited on 28 January 2023, at 19:29